743 results match your criteria [goodbye

Goodbye PAM: Phage λ's Red recombination system cripples PAMs and helps dodge CRISPR attacks.

Cell Host Microbe 2021 Oct;29(10):1469-1471

Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA. Electronic address:

Ever wondered how the phage λ Red recombination system resembles the Red Queen? Hossain et al. (2021) provide an answer in this issue of Cell Host & Microbe. They show that Red debilitates PAM sequences by mutagenic repair of CRISPR-targeted DNA breaks in infecting λ, thus shaping the phage-CRISPR arms race. Read More

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October 2021

Bereaved Parent Perspectives on the Benefits and Burdens of Technology Assistance among Children with Complex Chronic Conditions.

J Palliat Med 2021 Oct 7. Epub 2021 Oct 7.

Division of Critical Care, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.

Many children with complex chronic conditions (CCCs) are supported by medical technologies. The aim of this study was to understand bereaved parent perspectives on technology assistance among this unique population. Mixed methods design was used to analyze data from the cross-sectional Bereaved parents of children with CCCs who received care at a large academic institution in the United States and died between 2006 and 2015. Read More

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October 2021

Time to Say Goodbye to International Neurourology Journal.

Hong Sang Moon

Int Neurourol J 2021 Sep 30;25(3):181. Epub 2021 Sep 30.

Department of Urology, Hanyang University College of Medicine, Seoul, Korea.

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September 2021

"Saying goodbye all alone with no close support was difficult"- Dying during the COVID-19 pandemic: an online survey among bereaved relatives about end-of-life care for patients with or without SARS-CoV2 infection.

BMC Health Serv Res 2021 Sep 22;21(1):998. Epub 2021 Sep 22.

Department of Palliative Medicine, Faculty of Medicine and University Hospital, University of Cologne, Kerpener Street 62, 50937, Cologne, Germany.

Background: During the SARS-CoV2 pandemic, protection measures, as well as visiting restrictions, had a severe impact on seriously ill and dying patients and their relatives. The study aims to describe the experiences of bereaved relatives of patients who died during the SARS-CoV2 pandemic, regardless of whether patients were infected with SARS-CoV2 or not. As part of this, experiences related to patients' end-of-life care, saying goodbye, visiting restrictions and communication with the healthcare team were assessed. Read More

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September 2021

I can't believe they are dead. Death and mourning in the absence of goodbyes during the COVID-19 pandemic.

Health Soc Care Community 2021 Aug 7. Epub 2021 Aug 7.

Department of Sociology and Social Work, Universidad Pontificia Comillas, Madrid, Spain.

The circumstances surrounding the deaths during the COVID-19 pandemic and the subsequent mourning process transpired in completely atypical conditions. This study analyses the experience of losing a loved one without traditional, culture-specific rituals for saying goodbye, explores the different factors affecting the onset of mourning by family members and studies the existence of complicating risk factors associated with grief from this distinct type of loss. A qualitative, phenomenological and interpretive research study was undertaken through in-depth interviews of 48 informants, key and general, in the autonomous Community of Madrid. Read More

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Effect of wall type, delayed mortality and mosquito age on the residual efficacy of a clothianidin-based indoor residual spray formulation (SumiShield™ 50WG) in southern Mozambique.

PLoS One 2021 5;16(8):e0248604. Epub 2021 Aug 5.

Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.

Indoor residual spraying (IRS) is one of the main malaria vector control strategies in Mozambique alongside the distribution of insecticide treated nets. As part of the national insecticide resistance management strategy, Mozambique introduced SumiShield™ 50WG, a third generation IRS product, in 2018. Its residual efficacy was assessed in southern Mozambique during the 2018-2019 malaria season. Read More

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3+7 Combined Chemotherapy for Acute Myeloid Leukemia: Is It Time to Say Goodbye?

Curr Oncol Rep 2021 Aug 4;23(10):120. Epub 2021 Aug 4.

Division of Medical Oncology and Hematology, University Health Network - Princess Margaret Cancer Centre, 610 University Avenue, 700 U 6th Floor, Toronto, Ontario, M5G 2M9, Canada.

Purpose Of Review: With the recent approval of multiple new drugs for the treatment of acute myeloid leukemia (AML), the relevance of conventional treatment approaches, such as daunorubicin and cytarabine ("3+7") induction chemotherapy, has been challenged. We review the AML risk stratification, the efficacy of the newly approved drugs, and the role of "3+7".

Recent Findings: Treatment of AML is becoming more niched with specific subtypes more appropriately treated with gemtuzumab, midostaurin, and CPX-351. Read More

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Goodbye Hippocrates?

Michael Ashby

J Bioeth Inq 2021 07;18(2):195-198

Cancer, Chronic Disease and Sub-Acute Stream, Royal Hobart Hospital, Tasmanian Health Service, School of Medicine, University of Tasmania, Royal Hobart Hospital, Hobart, TAS, 7000, Australia.

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Reflecting on meaning in an existential-reorientation group psychotherapy approach for cancer patients: A qualitative thematic analysis.

Palliat Support Care 2021 Jul 19:1-8. Epub 2021 Jul 19.

Department of Philosophy, Sociology, Education and Applied Psychology (FISPPA), University of Padova, Padova, Italy.

Objective: The objectives of this study were to evaluate, in the Italian cultural context, breast cancer patients' main meaning themes related to the experience of the disease, on the one side, and to be part of an existentially oriented group intervention, on the other.

Method: A short reorientation-existential (RET) group intervention, structured by using some tools and background from cognitive analytic therapy (CAT) and based on the meaning-centered psychotherapy (MCP) existential framework, was delivered to 29 breast cancer patients. The sessions were audio-recorded and transcribed verbatim, with the narratives from reflective exercises (meaning of the journey cancer, meaning of the journey of intervention) uploaded to computer software NVivo 11. Read More

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Goodbye John.

EMBO J 2021 Jul 29;40(14):e108887. Epub 2021 Jun 29.

Human Technopole, Palazzo Italia, Milan, Italy.

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Rapid on-site evaluation in the era of EUS-FNB: really time to say goodbye?

Jun Li Feng Liu

Gastroenterology 2021 Jun 24. Epub 2021 Jun 24.

Digestive Endoscopy Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address:

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Impact of End-of-Life Circumstances on the Adjustment of Bereaved Siblings of Children Who Died from Cancer.

J Clin Psychol Med Settings 2021 Jun 26. Epub 2021 Jun 26.

Center for Biobehavioral Health, The Abigail Wexner Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA.

The aim of this study was to examine the impact of end-of-life (EoL) circumstances on grief and internalizing symptoms among bereaved siblings. Bereaved families (N = 88) were recruited from three sites 3-12 months (M = 11.57, SD = 3. Read More

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End of Life Intervention Program During COVID-19 in Vall d'Hebron University Hospital.

Front Psychiatry 2021 3;12:608973. Epub 2021 May 3.

Department of Psychiatry, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.

The coronavirus disease 19 (COVID-19) and its consequences have placed our societies and healthcare systems under pressure. Also, a major impact on the individual and societal experience of death, dying, and bereavement has been observed. Factors such as social distancing, unexpected death or not being able to say goodbye, which might predict Prolonged Grief Disorder (PGD), are taking place. Read More

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Sadness, despair and anger when a patient dies alone from COVID-19: A thematic content analysis of Twitter data from bereaved family members and friends.

Palliat Med 2021 07 21;35(7):1267-1276. Epub 2021 May 21.

Department for Medicine for Older People, North Bristol NHS Trust, Bristol, UK.

Background: To inform clinical practice and policy, it is essential to understand the lived experience of health and social care policies, including restricted visitation policies towards the end of life.

Aim: To explore the views and experiences of Twitter social media users who reported that a relative, friend or acquaintance died of COVID-19 without a family member/friend present.

Design: Qualitative content analysis of English-language tweets. Read More

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'Saying goodbye' during the COVID-19 pandemic: A document analysis of online newspapers with implications for end of life care.

Palliat Med 2021 07 21;35(7):1277-1287. Epub 2021 May 21.

School of Health, Wellbeing and Social Care, The Open University, Milton Keynes, UK.

Background: News media create a sense-making narrative, shaping, reflecting and enforcing cultural ideas and experiences. Reportage of COVID-related death and bereavement illuminates public perceptions of, and responses to, the COVID-19 pandemic.

Aim: We aimed to explore British newspaper representations of 'saying goodbye' before and after a COVID-related death and consider clinical implications. Read More

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The long goodbye on a disappearing, ancestral island: a just retreat from Isle de Jean Charles.

J Environ Stud Sci 2021 May 13:1-13. Epub 2021 May 13.

University of New Orleans, New Orleans, LA USA.

Climate change will necessitate evermore frequent and complex managed retreats in the future, and drafting policies that are equitable and just for those residents who are relocating will be essential. The USA's first federally funded, community-scale, climate-driven resettlement is currently underway in coastal Louisiana. In January 2016, the U. Read More

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Pediatric and adult epileptologist perspectives and experiences of pediatric to adult epilepsy care transition: "Saying goodbye and opening a door."

Epilepsy Behav 2021 07 4;120:107981. Epub 2021 May 4.

Department of Neurology, University of Colorado School of Medicine, Aurora, CO, United States. Electronic address:

We aimed to describe perspectives of transition and transfer of adolescents and young adults with childhood-onset epilepsy from pediatric to adult care from the viewpoints of both pediatric and adult epileptologists. Telephone semi-structured interviews with pediatric (n = 15) and adult (n = 11) epileptologists at leading U.S. Read More

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Authors' reply: PSMA-PET: is the time to say goodbye to metabolic radiopharmaceuticals in prostate cancer?

Eur J Nucl Med Mol Imaging 2021 07 4;48(8):2307-2308. Epub 2021 May 4.

Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, CH-3010, Bern, Switzerland.

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Continuous Palliative Sedation Until Death: The Development of a Practice Protocol for Nursing Homes.

J Am Med Dir Assoc 2021 Aug 28;22(8):1776.e1-1776.e7. Epub 2021 Apr 28.

End-of-Life Care Research Group, Vrije Universiteit Brussel (VUB) and Ghent University, Brussels, Belgium; Department of Family Medicine and Chronic Care, Vrije Universiteit Brussel (VUB), Brussels, Belgium; Department of Public Health & Primary Care, Ghent University, Ghent, Belgium.

Objectives: Challenges inherent in the practice of continuous palliative sedation until death appear to be particularly pervasive in nursing homes. We aimed to develop a protocol to improve the quality of the practice in Belgian nursing homes.

Methods: The development of the protocol was based on the Medical Research Council Framework and made use of the findings of a systematic review of existing improvement initiatives and focus groups with 71 health care professionals [palliative care physicians, general practitioners (GPs), and nursing home staff] identifying perceived barriers to the use of continuous palliative sedation until death in nursing homes. Read More

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Kiss goodbye to the 'kissing knees': no association between frontal plane inward knee motion and risk of future non-contact ACL injury in elite female athletes.

Sports Biomech 2021 Apr 28:1-15. Epub 2021 Apr 28.

Oslo Sports Trauma Research Center, Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway.

The aim of this study was to investigate if frontal plane knee and hip control in single-leg squats or vertical drop jumps with an overhead target were associated with future non-contact anterior cruciate ligament (ACL) injury in elite female athletes. Of the 429 handball and 451 football athletes (age 21.5 ± 4. Read More

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India's Universal Mega-dose Vitamin A Supplement Program: Time to Bid Goodbye!

Piyush Gupta

Indian Pediatr 2021 04;58(4):311-312

Professor and Head, Department of Pediatrics, University College of Medical Sciences, Delhi, India.

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Goodbye fouling: a unique coaxial lamination mixer (CLM) enabled by two-photon polymerization for the stable production of monodisperse drug carrier nanoparticles.

Lab Chip 2021 06;21(11):2178-2193

Technische Universität Braunschweig, Institut für Mikrotechnik, Alte Salzdahlumer Str. 203, 38124 Braunschweig, Germany. and Technische Universität Braunschweig, Zentrum für Pharmaverfahrenstechnik (PVZ), Franz-Liszt-Str. 35a, 38106 Braunschweig, Germany.

Poorly soluble drugs can be incorporated in lipid carrier nanoparticles to achieve sufficient bioavailability and open up diverse routes of administration. Preparation by antisolvent precipitation in microfluidic systems enables excellent control of lipid nanoparticle size. However, particle-containing flows bear the risk of material deposition on microchannel surfaces, limiting reproducibility, prolonged continuous processing and scale-up by parallelization as required for practical use. Read More

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A brief cognitive-behavioural treatment approach for PTSD and Dissociative Identity Disorder, a case report.

J Behav Ther Exp Psychiatry 2021 Sep 2;72:101655. Epub 2021 Apr 2.

HSK Groep B.V., Centre of Expertise Functional Movement Disorders, Woerden, The Netherlands. Electronic address:

Background And Objectives: We described a new treatment model for Posttraumatic Stress Disorder (PTSD) and Dissociative Identity Disorder (DID), based on cognitive-behavioural principles. In this model, dissociation is seen as a maladaptive avoidant coping strategy. In addition, we stress that patients have dysfunctional beliefs about dissociation. Read More

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September 2021

Impact and consequences of COVID-19 pandemic on complicated grief and persistent complex bereavement disorder.

Psychiatry Res 2021 06 31;300:113916. Epub 2021 Mar 31.

University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Italy.

Mourning is a coping-with-loss stage that prevents grief from becoming pathologic, i.e., complicated grief (CG) syndrome and persistent complex bereavement disorder (PCBD), recently included in international classification systems. Read More

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A qualitative study of bereaved relatives' end of life experiences during the COVID-19 pandemic.

Palliat Med 2021 05 30;35(5):843-851. Epub 2021 Mar 30.

Palliative Care Institute Liverpool, North West Cancer Research Centre, University of Liverpool, Liverpool, UK.

Background: Meeting the needs of relatives when a family member is dying can help facilitate better psychological adjustment in their grief. However, end of life experiences for families are likely to have been deleteriously impacted by the COVID-19 crisis. Understanding how families' needs can be met during a global pandemic will have current/future relevance for clinical practice and policy. Read More

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Improving the reach of clinical practice guidelines: An experimental investigation of message framing on user engagement.

Clin Psychol Sci 2020 Sep 2;8(5):825-838. Epub 2020 Jul 2.

University of Virginia, Department of Psychology.

Despite strong evidence for the efficacy of PTSD treatments, most affected individuals are not receiving these treatments, in part because they may not know that evidence-based treatments exist. The American Psychological Association published a website to disseminate information about their Clinical Practice Guideline for treating PTSD. In Study 1, Google Optimize was used in a field study to examine whether altering the subheadings to three of the website pages would increase site visitor engagement. Read More

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September 2020