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A retrospective evaluation of the value of COVID-19 screening and testing in patients with cancer: Aiming at a moving target.

J Infect Public Health 2021 May 26;14(7):949-953. Epub 2021 May 26.

Department of Oncology, King Abdulaziz Medical City, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs (MNGHA), Riyadh, Saudi Arabia.

Background: Diagnosis of COVID-19 infection in cancer patients is critical to co-manage their underlying disease and infection appropriately. Our study aimed at evaluating the sensitivity and specificity of screening patients with cancer for COVID-19 infection.

Methods: All oncology patients receiving care at Department of Oncology at King Abdulaziz Medical City in Riyadh were screened using the acute respiratory infection (ARI) survey. Read More

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First Report of Bacterial Rot Caused by Pantoea endophytica on Tobacco in Liuyang, China.

Plant Dis 2021 Jun 15. Epub 2021 Jun 15.

Chinese Academy of Agricultural Sciences Institute of Tobacco Research, 243822, Qingdao, Shandong, China;

Tobacco, Nicotiana tabacum L., is produced largely in China (~1/3 of the global market). In the monsoon summer of 2020, tobacco plant petioles, where axillary buds were removed, became black-rotten, and thick ooze appeared, when squeezed. Read More

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Which radiograph is most accurate for assessing hip joint penetration in infra-acetabular screw placement?

Medicine (Baltimore) 2021 Jun;100(24):e26392

Department of Orthopedic Surgery, Korea University Guro Hospital, Korea University Medical Center, Seoul, Republic of Korea.

Abstract: Although infra-acetabular screws have been used for anterior and posterior column transfixation, a screw penetrating the hip joint can result in harmful complications. However, the most accurate intraoperative radiologic imaging tool for identifying articular penetration has not been established. The purpose of the present study was, therefore, to evaluate the consistency with which standard pelvic radiographs compared with computed tomography (CT) can be used for demonstrating articular penetration. Read More

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Development of a preoperative prediction model for new-onset diabetes mellitus after partial pancreatectomy: A retrospective cohort study.

Medicine (Baltimore) 2021 Jun;100(24):e26311

Department of Healthcare Epidemiology, School of Public Health in the Graduate School of Medicine.

Abstract: Pancreatectomy is an invasive surgery that is sometimes associated with complications. New-onset diabetes mellitus sometimes develops after partial pancreatectomy and severely affects the patient's quality of life. This study aimed to develop a preoperative prediction model of new-onset diabetes mellitus after partial pancreatectomy, which will help patients and surgeons to achieve more easily better common decisions on regarding whether to perform partial pancreatectomy. Read More

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Treatment Guideline for Patients with Native Culture-negative Pyogenic Vertebral Osteomyelitis.

Clin Orthop Relat Res 2021 Jun 15. Epub 2021 Jun 15.

Spine Center, Department of Orthopedics, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.

Background: With the development of evidence-based guidelines for the diagnosis and antibiotic treatment of patients with pyogenic vertebral osteomyelitis, various nonsurgical and surgical treatment strategies have achieved favorable results. However, sufficient administration of appropriate antibiotics is a prerequisite for treatment success, which cannot be guaranteed in patients with culture-negative pyogenic vertebral osteomyelitis. Unfortunately, previous studies on culture-negative pyogenic vertebral osteomyelitis were limited by small patient groups, short follow-up periods, varied treatment protocols, and inconsistently defined clinical endpoints. Read More

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Reliable detection of subtypes of nailfold capillary haemorrhages in childhood-onset systemic lupus erythematosus.

Clin Exp Rheumatol 2021 Jun 8. Epub 2021 Jun 8.

Department of Internal Medicine, Ghent University, and Department of Rheumatology, Ghent University Hospital, Ghent, Belgium.

Objectives: In systemic lupus erythematosus (SLE), it is necessary to obtain biomarkers that predict cardiovascular complications due to premature atherosclerosis, which is related to endothelial dysfunction. Nailfold capillary abnormalities might be a biomarker for endothelial dysfunction. In adults and children with SLE, nailfold capillary haemorrhages have shown to be significantly correlated with disease activity. Read More

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Cumulative Impacts and COVID-19: Implications for Low-Income, Minoritized, and Health-Compromised Communities in King County, WA.

J Racial Ethn Health Disparities 2021 Jun 14. Epub 2021 Jun 14.

Department of Environmental & Occupational Health Sciences, University of Washington, Seattle, WA, USA.

Few studies have assessed how the intersection of social determinants of health and environmental hazards contributes to racial disparities in COVID-19. The aim of our study was to compare COVID-19 disparities in testing and positivity to cumulative environmental health impacts, and to assess how unique social and environmental determinants of health relate to COVID-19 positivity in Seattle, King County, WA, at the census tract level. Publicly available data (n = 397 census tracts) were obtained from Public Health-Seattle & King County, 2018 ACS 5-year estimates, and the Washington Tracking Network. Read More

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Evolution of surgical attitudes to paediatric thalamic tumours: the alder hey experience.

Childs Nerv Syst 2021 Jun 14. Epub 2021 Jun 14.

Department of Paediatric Neurosurgery, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.

Purpose: Attitudes to surgery for paediatric thalamic tumours have evolved due to improved preoperative imaging modalities and the advent of intraoperative MRI (iMRI) as well as enhanced understanding of tumour biology. We review the developments in our local practice over the last three decades with particular attention to the impact of iMRI.

Methods: We identified all paediatric patients from a prospectively maintained neuro-oncology database who received surgery for a thalamic tumour (n = 30). Read More

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Fecal short-chain fatty acids and obesity in a community-based Japanese population: The DOSANCO Health Study.

Obes Res Clin Pract 2021 Jun 11. Epub 2021 Jun 11.

Department of Public Health, Faculty of Medicine, Hokkaido University, N15, W7, Kita-ku, Sapporo 060-8638, Japan.

In Western populations, fecal concentrations of short-chain fatty acids (SCFAs) are positively correlated with the prevalence of obesity. However, gut microbiota involved in the production of SCFA varies between races. Our purpose was to investigate the associations between fecal SCFAs and the prevalence of obesity in a community-based Japanese population. Read More

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Is it necessary to add the eluate testing to the direct antiglobulin test to improve the detection of maternal erythrocyte alloantibodies?

Transfus Apher Sci 2021 Jun 3:103177. Epub 2021 Jun 3.

University of Antioquia, Medellín, Colombia.

Background: The screening of umbilical cord blood samples by the Direct Antiglobulin Test (DAT) is the reference tool for the identification of maternal erythrocyte alloantibodies present in erythrocytes; however, its diagnostic usefulness is controversial.

Objective: To evaluate the diagnostic validity, safety, and efficiency of the eluate testing (detection of antibody in erythrocyte eluates by the Indirect Antiglobulin Test/IAT) in cord blood samples for detection of maternal erythrocyte alloantibodies in comparison with the DAT.

Materials And Methods: Evaluation study of diagnostic tests. Read More

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Long-Term Efficacy and Safety of Deutetrabenazine for Chorea in Huntington's Disease: Results From the ARC-HD Open-label Study.

CNS Spectr 2021 Apr;26(2):164-165

Teva Pharmaceutical Industries Ltd., Basel, Switzerland.

Background: Chorea is a prominent motor dysfunction in Huntington's disease (HD). Deutetrabenazine, a vesicular monoamine transporter 2 (VMAT2) inhibitor, is FDA-approved for the treatment of chorea in HD. In the pivotal, 12-week First-HD trial, deutetrabenazine treatment reduced the Unified Huntington's Disease Rating Scale (UHDRS) total maximal chorea (TMC) score versus placebo. Read More

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Co-occurrence subgroups of child sexual abuse, health risk behaviors and their associations among secondary school students in China.

BMC Public Health 2021 Jun 14;21(1):1139. Epub 2021 Jun 14.

School of Public Health, Fudan University, 779 Laohumin Road, Shanghai, 200237, China.

Background: Little is known on the co-occurrence and heterogeneity of child sexual abuse (CSA) or health risk behavior (HRB) prevalence nor the associations among the victims.

Objectives: To detect the prevalence and subgroups of adolescents reporting CSAs or HRBs, and to examine the association between the subgroups.

Methods: Participants were secondary school students in a national survey in China (N = 8746). Read More

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Biodegradation of an essential oil UVCB - Whole substance testing and constituent specific analytics yield biodegradation kinetics of mixture constituents.

Chemosphere 2021 Sep 1;278:130409. Epub 2021 Apr 1.

Technical University of Denmark, Department of Environmental Engineering, Building 115, 2800 Kgs, Lyngby, Denmark. Electronic address:

Testing and assessing the persistency, bioaccumulative and toxic properties of UVCBs (substances of Unknown or Variable composition, Complex reaction products or Biological materials) pose major technical and analytical challenges. The main aim of this study was to combine whole substance biodegradation testing with constituent specific analytics for determining primary biodegradation kinetics of the main UVCB constituents. An additional aim was to link the primary biodegradation kinetics of the main constituents to the bioaccumulation potential and baseline toxicity potential of the UVCB. Read More

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September 2021

Concentration factors and biological half-lives for the dynamic modelling of radionuclide transfers to marine biota in the English Channel.

Sci Total Environ 2021 Jun 5;791:148193. Epub 2021 Jun 5.

Laboratoire de Radioécologie de Cherbourg-Octeville, Institut de Radioprotection et de Sûreté Nucléaire/PSE-ENV/SRTE, Rue Max Pol Fouchet, BP10, 50130 Cherbourg-en-Cotentin, France. Electronic address:

The biokinetics of radionuclide transfers to biota in the marine environment can be modelled using two parameters, specific to both each element/radionuclide and biota. The Concentration Factor (CF) reflects the ratio between the activity concentrations in the biota and the surrounding seawater in steady state. The biological half-life (tb) characterizes depuration kinetics for the radionuclide from the biota. Read More

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Long-term outcomes and periprocedural safety and efficacy of percutaneous left atrial appendage closure in a UK tertiary centre: 11-year experience.

Heart Rhythm 2021 Jun 11. Epub 2021 Jun 11.

Oxford University Hospitals NHS Trust, Oxford, UK; University of Oxford, UK. Electronic address:

Background: Left atrial appendage occlusion (LAAO) has been widely adopted as a strategy for stroke prevention in patients with atrial fibrillation ineligible for oral anticoagulation.

Objective: To explore longer term "real-world" safety and efficacy outcomes in patients undergoing LAAO given varied practice in antithrombotic regimes and adoption of same-day-discharge.

Methods: Analysis of acute procedural and long-term outcome data was performed for all patients undergoing LAAO implant in a UK tertiary centre over a 11-year period. Read More

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The calculated versus the measured glycosylated haemoglobin (HbA ) levels in patients with type 2 diabetes mellitus.

J Clin Lab Anal 2021 Jun 14:e23873. Epub 2021 Jun 14.

Department of Obstetrics and Gynecology, Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, Saudi Arabia.

Background: Diabetes mellitus (DM) is a chronic metabolic disorder that is increasing globally. It is associated with chronic complications that are more common among patients with poor glycaemic control. Glycosylated haemoglobin (HbA ) is the gold standard for monitoring glycaemic control. Read More

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Atrial fibrillation risk scores to evaluate left atrial substrate based on voltage analysis in long-standing persistent type of arrhythmia.

Kardiol Pol 2021 ;79(5):525-530

Cardiology Department, Pomeranian Medical University, Szczecin, Poland.

Background: Pre-ablation identification of left atrial (LA) low voltage areas (LVA) among long-standing persistent atrial fibrillation (LSPAF) population remains challenging.

Aims: The aim of the study was to analyze the potential of selected scores originally developed to assess arrhythmia recurrences, thromboembolic complications, or progression from paroxysmal to persistent AF to predict the presence of LA-LVA in LSPAF patients.

Methods: One hundred and fifty-two patients underwent pulmonary vein isolation followed by high-density-high-resolution LA voltage mapping. Read More

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January 2021

Deep learning for discovering pathological continuum of crypts and evaluating therapeutic effects: An implication for in vivo preclinical study.

PLoS One 2021 14;16(6):e0252429. Epub 2021 Jun 14.

Global Computational Biology and Digital Sciences, Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut, United States of America.

Applying deep learning to the field of preclinical in vivo studies is a new and exciting prospect with the potential to unlock decades worth of underutilized data. As a proof of concept, we performed a feasibility study on a colitis model treated with Sulfasalazine, a drug used in therapeutic care of inflammatory bowel disease. We aimed to evaluate the colonic mucosa improvement associated with the recovery response of the crypts, a complex histologic structure reflecting tissue homeostasis and repair in response to inflammation. Read More

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Elective abdominal wall hernia repair surgical mortality-A systematic review of the literature and peer review of mortality in Australia.

ANZ J Surg 2021 Jun 14. Epub 2021 Jun 14.

Department of Surgery, The University of Adelaide, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia.

Background: This study systematically reviewed the literature regarding perioperative mortality in human adults undergoing elective surgical abdominal wall hernia repair, including an audit of the Royal Australasian College of Surgeons (RACS) Australian and New Zealand Audit of Surgical Mortality (ANZASM) database.

Methods: A systematic review was conducted in accordance with PRISMA guidelines for the reporting of systematic reviews and meta-analysis of observational studies. Cochrane Library, PubMed, MEDLINE and Embase database searches and data extraction were conducted from June 1979 to October 2019. Read More

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A nomogram to predict overall survival and disease-free survival after curative-intent gastrectomy for gastric cancer.

Updates Surg 2021 Jun 14. Epub 2021 Jun 14.

First Surgical Clinic, Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), University of Padua, Padua, Italy.

An individual prediction of DFS and OS may be useful after surgery for gastric cancer to inform patients and to guide the clinical management. Patients who underwent curative-intent resection for gastric cancer between January 2010 and May 2020 at a single Italian institution were identified. Variables associated with OS and DFS were recorded and analysed according to univariable and multivariable Cox models. Read More

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In vitro targeting and selective killing of mcf-7 and colo320dm cells by 5-fluorouracil anchored to carboxylated SWCNTs and MWCNTs.

J Mater Sci Mater Med 2021 Jun 14;32(6):71. Epub 2021 Jun 14.

Department of Pharmaceutics, RCP, Kasegaon, Maharashtra, 415 404, India.

The intention of the present work was to synthesize the f-MWCNT and f-SWCNT terminated with proper functional group, loading of 5-Flurouracil and to perform cytotoxic activity. Functionalization of MWCNTs and SWCNTs was achieved through the acid treatment (HSO + HNO). 5-flurouracil was loaded into the prepared functionalized CNTs, thereafter; in vitro drug loading capacity and % drug release were calculated. Read More

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Sport Concussion Assessment Tool-5th Edition (SCAT5): Normative Reference Values for the National Rugby League Women's Premiership.

Front Sports Act Living 2021 26;3:653743. Epub 2021 May 26.

Hunter New England Local Health District Sports Concussion Program, Newcastle, NSW, Australia.

To establish normative reference values for the Sport Concussion Assessment Tool-5th Edition (SCAT5) for the new National Rugby League Women's Premiership. Preseason SCAT5 baseline testing was administered individually to all National Rugby League Women's Premiership players ( = 117). Testing was completed by the medical staff. Read More

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Assessing the Impact of Wildfires on the Use of Black Carbon as an Indicator of Traffic Exposures in Environmental Epidemiology Studies.

Geohealth 2021 Jun 1;5(6):e2020GH000347. Epub 2021 Jun 1.

Environmental and Radiological Health Sciences Colorado State University Fort Collins CO USA.

Epidemiological studies frequently use black carbon (BC) as a proxy for traffic-related air pollution (TRAP). However, wildfire smoke (WFS) represents an important source of BC not often considered when using BC as a proxy for TRAP. Here, we examined the potential for WFS to bias TRAP exposure assessments based on BC measurements. Read More

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Numerical Simulations of the Influence of Inert Gases (N/CO) on Combustion Characteristics of Laminar-Premixed Biosyngas Flame.

ACS Omega 2021 Jun 25;6(22):14585-14597. Epub 2021 May 25.

College of Mechanical and Electronic Engineering, Shandong University of Science and Technology, Qingdao 266590, China.

In this work, the influence of different N/CO contents (up to 60% in fuel volume) on combustion features of laminar-premixed CO/CH/H flame with various equivalence ratios (0.6-1.6) at standard conditions was numerically calculated using ANSYS CHEMKIN-PRO with the GRI-Mech 3. Read More

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Mesoscopic Seepage Simulation and Analysis of Unclassified Tailings Pores Based on 3D Reconstruction Technology.

ACS Omega 2021 Jun 24;6(22):14309-14316. Epub 2021 May 24.

New Metallurgy Hi-Tech Group, China Iron and Steel Research Institute, Beijing 100081, China.

Taking the unclassified tailings as the research object, the three-dimensional (3D) pore model was established using computed tomography (CT) scanning technology, image processing, and the 3D reconstruction method. The model was imported into Flac3D software for mesoscopic seepage simulation and analysis. Combined with the laboratory seepage experiment, the influence of tailings' mesoscopic parameters on permeability was explored. Read More

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Patient-Reported Outcome Following Operative and Conservative Treatment of Calcaneal Fractures: A Retrospective Analysis of 79 Patients at Short- to Midterm Follow-Up.

Front Surg 2021 28;8:620964. Epub 2021 May 28.

Department of Trauma Surgery, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.

Fractures of the calcaneus are severe injuries of the hindfoot, mostly resulting from high-energy axial loads, which still present enormous challenges to modern trauma surgery. Possible variables influencing the outcome are the type of fracture, age, and quality of fracture reduction. These might also be factors affecting the self-reported patient outcome, but large studies are still lacking. Read More

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Research on Characteristic of Chronic Spontaneous Urticaria Based on Multiscale Entropy.

Comput Math Methods Med 2021 25;2021:6691356. Epub 2021 May 25.

College of Mathematical Sciences, Harbin Engineering University, Harbin 150001, China.

Chronic spontaneous urticaria (CSU) is a common skin disease which symptom is local pruritus and pain. In medicine, researchers take a certain point that the brain is the control center of CSU, but in previous experiments, the researchers found that cerebellum also had a certain effect on CSU. In order to find out the influence of CSU in the brain and cerebellum, we collected the brain resting-state fMRI data from 40 healthy controls and 32 CSU patients and used DPABI to preprocess. Read More

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Pharmacokinetic Study of Oral C-Radiolabeled Hyzetimibe, A New Cholesterol Absorption Inhibitor.

Front Pharmacol 2021 28;12:665372. Epub 2021 May 28.

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China.

Hyzetimibe is a candidate drug being investigated as the second-in-class cholesterol absorption inhibitor; it lowers plasma levels of low-density lipoprotein cholesterol (LDL-C) by blocking the Niemann-Pick C1-like 1 protein, a transporter mainly expressed in the intestine that allows dietary cholesterol to enter the body from the intestinal lumen. Previous studies on the metabolism of hyzetimibe in healthy volunteers were not enough to show the biotransformation and excretion pathway; in particular, whether hyzetimibe maintains pharmacological action for duration sufficient to pass through the hepatic-intestinal circulation remains unknown. Furthermore, it remains unclear whether the differences between the chemical structures of ezetimibe and hyzetimibe would result in different pharmacokinetic characteristics. Read More

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Management of Adults with Acute Oesophageal Soft Food Bolus and Foreign Body Obstructions at Two New Zealand District Health Boards.

Clin Exp Gastroenterol 2021 4;14:237-247. Epub 2021 Jun 4.

Department of Gastroenterology, Waitemata District Health Board, Auckland, New Zealand.

Aim: 1. Investigate the characteristics of adult patients presenting with acute oesophageal soft food bolus obstruction (SFBO) and impacted foreign body (IFB) at two New Zealand district health boards (DHBs). 2. Read More

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Fruit and vegetable consumption before and during pregnancy and developmental delays in offspring aged 2 years in Japan.

Br J Nutr 2021 Jun 14:1-28. Epub 2021 Jun 14.

Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8573, Japan.

The association between fruit and vegetable consumption before and during pregnancy and offspring's physical growth has been well reported, but no study has focused on offspring's neurological development. We aimed to explore the association between maternal fruit and vegetable consumption before and during pregnancy and developmental delays in their offspring aged 2 years. Between July 2013 and March 2017, 23,406 women were recruited for the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Read More

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