61 results match your criteria =-0423 p = 0011


Tumor budding in cervical cancer as a prognostic factor and its possible role as an additional intermediate-risk factor.

Gynecol Oncol 2020 10 31;159(1):157-163. Epub 2020 Jul 31.

Department of Obstetrics and Gynecology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea; Department of Obstetrics and Gynecology, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea.

Objective: To evaluate the prognostic value and its possible role as an additional intermediate-risk factor of tumor budding (TB) in cervical cancer following radical hysterectomy.

Methods: In total, 136 patients with cervical cancer who underwent radical hysterectomy with pelvic and/or paraaortic lymphadenectomy were included. We assessed the status of TB in available hematoxylin and eosin-stained specimens. Read More

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October 2020

Behaviour change physiotherapy intervention to increase physical activity following hip and knee replacement (PEP-TALK): study protocol for a pragmatic randomised controlled trial.

BMJ Open 2020 07 19;10(7):e035014. Epub 2020 Jul 19.

College of Medicine and Health Sciences, University of Exeter, Exeter, Devon, UK.

Introduction: While total hip replacement (THR) and total knee replacement (TKR) successfully reduce pain associated with chronic joint pathology, this infrequently translates into increased physical activity. This is a challenge given that over 50% of individuals who undergo these operations are physically inactive and have medical comorbidities such as hypertension, heart disease, diabetes and depression. The impact of these diseases can be reduced with physical activity. Read More

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Mucinous adenocarcinoma is a pharmacogenomically distinct subtype of colorectal cancer.

Pharmacogenomics J 2020 06 10;20(3):524-532. Epub 2019 Dec 10.

Department of Colorectal Surgery, Beaumont Hospital, Dublin 9, Ireland.

Mucinous colorectal cancer is a unique histological subtype that is known to respond poorly to cytotoxic chemotherapy and radiotherapy. There are a number of genes known to be associated with resistance to 5-fluorouracil (5-FU), oxaliplatin, and irinotecan. The aim of this study was to compare the somatic mutation frequency and copy number variation (CNV) in these genes between mucinous and non-mucinous colorectal cancer. Read More

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Role of Immune Response, Inflammation, and Tumor Immune Response-Related Cytokines/Chemokines in Melanoma Progression.

J Invest Dermatol 2019 11 7;139(11):2352-2358.e3. Epub 2019 Jun 7.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Electronic address:

To investigate the role of tumor cytokines/chemokines in melanoma immune response, we estimated the proportions of immune cell subsets in melanoma tumors from The Cancer Genome Atlas, followed by evaluation of the association between cytokine/chemokine expression and these subsets. We then investigated the association of immune cell subsets, chemokines, and cytokines with patient survival. Finally, we evaluated the immune cell tumor-infiltrating lymphocyte (TIL) score for correlation with melanoma patient outcome in a separate cohort. Read More

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November 2019

Overweight or Obesity is an Unfavorable Long-Term Prognostic Factor for Patients who Underwent Gastrectomy for Stage II/III Gastric Cancer.

World J Surg 2019 07;43(7):1766-1776

Department of Gastrointestinal Surgery, Japanese Red Cross Nagoya First Hospital, 3-35 Michishita-cho, Nakamura-ku, Nagoya, 453-8511, Japan.

Background: Obesity has been reported to be a prognostic factor for many diseases in epidemiological studies; however, the results of studies examining the relationship between obesity and gastric cancer (GC) prognosis are inconsistent.

Methods: A total of 460 patients with Stage II and III GC who underwent open R0 gastrectomy were included. Age, sex, body mass index (BMI classified into < 18. Read More

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[Expression of transforming growth factor 1 and bone morphogenetic protein 9 in human nonunion tissues and its clinical significance].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Jan;43(1):49-53

Deparment of Orthopedics, Suzhou Kowloon Hospital Affiliated to School of Medicine, Shanghai Jiao Tong University,Suzhou Jiangsu 215021, China.

Objective: To examine the expression of transforming growth factor 1(TGF-β1) and bone morphogenetic protein-9 (BMP-9) in human nonunion tissues, and to evaluate the clinical significance.
 Methods: The number of hypertrophic nonunion tissue samples and atrophic nonunion tissue samples were collected from Department of Orthopedics, the Second Xiangya Hospital of Central South University and Suzhou Kowloon Hospital Affiliated to School of Medicine of Shanghai Jiao Tong University between 2010 and 2014. Semi-quantification of SP immunohistochemical method and pathological image analysis software IPP6. Read More

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January 2018

Understanding How Chorea Affects Health-Related Quality of Life in Huntington Disease: An Online Survey of Patients and Caregivers in the United States.

Patient 2018 10;11(5):547-559

Department of Physical Medicine and Rehabilitation, University of Michigan, 500 S. State Street, Ann Arbor, MI, 48109, USA.

Background: Chorea is the hallmark motor feature of Huntington disease (HD) and can negatively impact daily functioning and health-related quality of life (HRQoL).

Objective: The objective of this study was to evaluate how chorea impacts HRQoL and overall functioning among HD patients participating on the PatientsLikeMe website ( www.PatientsLikeMe. Read More

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October 2018

Development of Azeliragon, an Oral Small Molecule Antagonist of the Receptor for Advanced Glycation Endproducts, for the Potential Slowing of Loss of Cognition in Mild Alzheimer's Disease.

J Prev Alzheimers Dis 2018 ;5(2):149-154

Larry Altstiel, MD, PhD, vTv Therapeutics LLC, 4170 Mendenhall Oaks Parkway, High Point, NC 27265, Email: Phone: 336-888-0423, Fax: 336-841-0310.

Increasing evidence supports the role of the Receptor for Advanced Glycation Endproducts (RAGE) in the pathology of Alzheimer's disease. Azeliragon (TTP488) is an orally bioavailable small molecule inhibitor of RAGE in Phase 3 development as a potential treatment to slow disease progression in patients mild AD. Preclinical studies in animal models of AD (tgAPPSwedish/London) have shown azeliragon to decrease Aβ plaque deposition; reduce total Aβ brain concentration while increasing plasma Aβ levels; decreases sAPPβ while increasing sAPPα; reduce levels of inflammatory cytokines; and slow cognitive decline and improve cerebral blood flow. Read More

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December 2019

An association of spleen volume and aortic diameter in patients and in mice with abdominal aortic aneurysm.

BMC Surg 2017 Dec 15;17(1):134. Epub 2017 Dec 15.

Department of Vascular Surgery, Peking Union Medical College Hospital, No.1 Shuaifuyuan, Dongdan, Dongcheng District, Beijing, 100730, China.

Background: To investigate the potential mechanism of splenic enlargement in Ang II/APOE model and the associations between the spleen volume and the indices of abdominal aortic aneurysm (AAA) in human.

Methods: To investigate the changes of spleen volume on AAA formation, apolipoprotein E knockout (Apo E) mice were treated with Ang II (1000 ng/kg/min) up to 28 days to generate AAA. We used Magnetic Resonance Imaging (MRI), liquid measurement, H&E and immunohistochemistry to analyze the morphological or pathological changes of spleen. Read More

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December 2017

Overexpression of CTEN relates to tumor malignant potential and poor outcomes of adenocarcinoma of the esophagogastric junction.

Oncotarget 2017 Oct 20;8(48):84112-84122. Epub 2017 Sep 20.

Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachihirokoji, Kamigyo-ku, Kyoto, Japan.

Background: To detect a novel treatment target for adenocarcinoma of the esophagogastric junction (AEG), we tested whether C-terminal tensin-like (CTEN), a member of the tensin gene family and frequently overexpressed in various cancers, acts as a cancer-promoting gene through overexpression in AEG.

Materials And Methods: We analyzed 5 gastric adenocarcinoma (GC) cell lines and 104 primary AEG tumors curatively resected in our hospital between 2000 and 2010.

Results: CTEN overexpression was detected in GC cell lines (2/5 cell lines; 40%) and primary AEG tumor samples (35/104 cases; 34%). Read More

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October 2017

Biological function integrated prediction of severe radiographic progression in rheumatoid arthritis: a nested case control study.

Arthritis Res Ther 2017 Oct 25;19(1):244. Epub 2017 Oct 25.

Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea.

Background: Radiographic progression is reported to be highly heritable in rheumatoid arthritis (RA). However, previous study using genetic loci showed an insufficient accuracy of prediction for radiographic progression. The aim of this study is to identify a biologically relevant prediction model of radiographic progression in patients with RA using a genome-wide association study (GWAS) combined with bioinformatics analysis. Read More

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October 2017

Intrathecal 2-hydroxypropyl-β-cyclodextrin decreases neurological disease progression in Niemann-Pick disease, type C1: a non-randomised, open-label, phase 1-2 trial.

Lancet 2017 Oct 10;390(10104):1758-1768. Epub 2017 Aug 10.

Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD USA. Electronic address:

Background: Niemann-Pick disease, type C1 (NPC1) is a lysosomal storage disorder characterised by progressive neurodegeneration. In preclinical testing, 2-hydroxypropyl-β-cyclodextrins (HPβCD) significantly delayed cerebellar Purkinje cell loss, slowed progression of neurological manifestations, and increased lifespan in mouse and cat models of NPC1. The aim of this study was to assess the safety and efficacy of lumbar intrathecal HPβCD. Read More

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October 2017

Prognostic survival value of retropharyngeal lymph node involvement in sinonasal tumors: A retrospective, descriptive, and exploratory study.

Head Neck 2017 07 28;39(7):1421-1427. Epub 2017 Apr 28.

Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria.

Background: Sinonasal carcinomas are rare. The purpose of this study was for us to present our assessment of the effects of retropharyngeal lymph node involvement at diagnosis on patient outcomes.

Methods: Retropharyngeal lymph node involvement in 36 patients with sinonasal carcinoma was determined by radiology at initial presentation. Read More

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Teratomas of the cranial vault: a systematic analysis of clinical outcomes stratified by histopathological subtypes.

Acta Neurochir (Wien) 2017 03 14;159(3):423-433. Epub 2017 Jan 14.

Department of Neurosurgery, University of California, Los Angeles, 300 Stein Plaza, Los Angeles, 90095-1761, CA, USA.

Background: Teratomas of the cranial vault are divided into histopathological subtypes and grouped by prognoses: mature (good prognosis), mixed/malignant and immature teratomas (intermediate prognosis). This schema also includes non-teratomatous tumors. The authors of this study sought to elucidate histologically dependent predictors of survival and further clarify the classification system of intracranial teratomas. Read More

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[Efficacy of fenofibrate for hepatic steatosis in rats after severe burn].

Zhonghua Shao Shang Za Zhi 2016 May;32(5):277-82

Department of Burns and Plastic Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.

Objective: To observe the efficacy of fenofibrate for hepatic steatosis in rats after severe burn.

Methods: Twenty-seven male SD rats were divided into sham injury group, burn group, and burn+ fenofibrate group according to the random number table, with 9 rats in each group. Rats in sham injury group were sham injured on the back by immersing in 37 ℃ warm water for 15 s and then remained without other treatment. Read More

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Longitudinal Measurement of Pleural Fluid Biochemistry and Cytokines in Malignant Pleural Effusions.

Chest 2016 06 18;149(6):1494-500. Epub 2016 Jan 18.

Department of Respiratory Medicine, Sir Charles Gairdner Hospital, University of Western Australia, Perth, Australia; School of Medicine and Pharmacology, University of Western Australia, Perth, Australia; Pleural Medicine Unit, Institute of Respiratory Health, University of Western Australia, Perth, Australia. Electronic address:

Background: Malignant pleural effusion (MPE) is common. Existing literature on pleural fluid compositions is restricted to cross-sectional sampling with little information on longitudinal changes of fluid biochemistry and cytokines with disease progression. Indwelling pleural catheters provide the unique opportunity for repeated sampling and longitudinal evaluation of MPE, which may provide insight into tumor pathobiology. Read More

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Evaluation of efficacy and safety markers in a phase II study of metastatic colorectal cancer treated with aflibercept in the first-line setting.

Br J Cancer 2015 Sep 10;113(7):1027-34. Epub 2015 Sep 10.

Digestive Oncology, University Hospitals Leuven and KU Leuven, Leuven, Belgium.

Background: Aflibercept (ziv-aflibercept) is an anti-angiogenic agent recently approved in combination with FOLFIRI for the treatment of metastatic colorectal cancer (mCRC) patients previously treated with oxaliplatin. Despite heterogeneity in response to aflibercept, no biomarkers for efficacy or adverse effects have been identified. Here we present biomarker data from the randomised phase II AFFIRM trial assessing aflibercept in combination with mFOLFOX6 first line in mCRC. Read More

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September 2015

[Tight junction protein expression of gastric mucosa and its significance in children with Helicobacter pylori infection].

Zhonghua Er Ke Za Zhi 2015 Jul;53(7):510-5

Department of Gastroenterology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; Email:

Objective: To understand the junction protein expression of gastric mucosa including occlusal proteins (occludin), closed protein-4 (claudin-4), zonula occluden-1(ZO-1), epithelial cadherin (E-cadherin), and β ring protein (β-catenin) and the clinical significance in children with Helicobacter pylori (Hp) infection.

Method: Seventy patients in whom gastric endoscopy was performed because of nausea, vomiting, abdominal pain, bloating, acid reflux, melena, and other gastrointestinal symptoms were enrolled in this study from Dec. 2010 to Apr. Read More

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An endoscopic and pathological survey of digestive tract disorders in patients infected with human immunodeficiency virus monitored in the Clinic of Infectious Diseases from Tirgu Mures, Romania.

Rom J Morphol Embryol 2014 ;55(3):885-90

Department of Infectious Diseases, University of Medicine and Pharmacy of Tirgu Mures, Romania;

Unlabelled: Gastrointestinal symptoms are among the most frequent complaints of patients infected with human immunodeficiency virus (HIV).

Purpose: An endoscopic and histopathological survey of digestive tract diseases among HIV-infected patients monitored in the Clinic of Infectious Diseases I from Tirgu Mures, Romania.

Materials And Methods: Retrospective, observational study, on a group of 38 HIV-positive patients admitted to the Clinic of Infectious Diseases I from Tirgu Mures, Romania, during 2006-2013, undergoing upper/lower endoscopy. Read More

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Effects of experimentally induced infections of goldfish Carassius auratus with cyprinid herpesvirus 2 (CyHV-2) at various water temperatures.

Dis Aquat Organ 2014 Aug;110(3):193-200

Tamaki Laboratory, Aquatic Animal Health Division, National Research Institute of Aquaculture, Fisheries Research Agency, 224-1 Hiruta, Tamaki, Mie 519-0423, Japan.

In this study, we examined the influence of water temperature on the development of herpesviral haematopoietic necrosis (HVHN) in goldfish Carassius auratus after experimentally induced infection with cyprinid herpesvirus 2 (CyHV-2). In Expt 1, Ryukin goldfish were infected with CyHV-2 by intraperitoneal injection and maintained at 4 different water temperatures. Cumulative mortalities of the 15, 20, 25 and 30°C groups were 10, 90, 90 and 60%, respectively. Read More

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Associations between body mass and papillary thyroid cancer stage and tumor size: a population-based study.

J Cancer Res Clin Oncol 2015 Jan 12;141(1):93-8. Epub 2014 Aug 12.

School of Community Health Sciences, University of Nevada, Reno, 1664 North Virginia Street, MS 274, Reno, NV, 89557, USA.

Purpose: The incidence of large thyroid tumors has increased over the past decades, suggesting that improved diagnosis is not the only driver of increased thyroid cancer incidence. Obesity has recently been implicated as an independent risk factor for thyroid cancer in specific populations. We aimed to investigate whether thyroid tumor size and advanced stage of diagnosis is associated with the obesity epidemic, for the first time, in a US population-based cohort. Read More

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January 2015

Extracapsular lymph node involvement is associated with colorectal liver metastases and impact outcome after hepatectomy for colorectal metastases.

World J Surg 2014 Aug;38(8):2079-88

Department of General Surgical Science (Surgery I), Gunma University Graduate School of Medicine, Gunma University, 3-39-22 Showa-machi, Maebashi, 371-8511, Japan,

Background: Hepatic resection of metastatic colorectal cancer (CRC) has become the treatment of choice for patients after resection of the primary CRC. However, some patients do not benefit from immediate resection because of rapidly progressive disease. The aim of this study was to examine the prognostic value of extracapsular invasion (ECI) of lymph node (LN) metastasis of CRC with liver metastases following liver resection. Read More

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Diffuse myocardial fibrosis following tetralogy of Fallot repair: a T1 mapping cardiac magnetic resonance study.

Pediatr Radiol 2014 Apr 14;44(4):403-9. Epub 2014 Jan 14.

Labatt Family Heart Centre in the Department of Paediatrics and Department of Diagnostic Imaging, The Hospital for Sick Children, University of Toronto, 555 University Ave., Toronto, Canada, M5G 1X8.

Background: Adverse ventricular remodeling after tetralogy of Fallot (TOF) repair is associated with diffuse myocardial fibrosis.

Objective: The goal of this study was to measure post-contrast myocardial T1 in pediatric patients after TOF repair as surrogates of myocardial fibrosis.

Materials And Methods: Children after TOF repair who underwent cardiac magnetic resonance imaging with T1 mapping using the modified look-locker inversion recovery (MOLLI) sequence were included. Read More

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Microtubule-associated proteins in mesial temporal lobe epilepsy with and without psychiatric comorbidities and their relation with granular cell layer dispersion.

Biomed Res Int 2013 27;2013:960126. Epub 2013 Aug 27.

Ribeirao Preto Medical School, Department of Neurosciences and Behavior, University of Sao Paulo (USP), Avenida Bandeirantes 3900, 14049-900 Ribeirao Preto, SP, Brazil ; Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), USP, Avenida Bandeirantes 3900, 14049-900 Ribeirao Preto, SP, Brazil ; National Institute of Science and Technology in Translational Medicine (INCT-TM/CNPq), Avenida Bandeirantes 3900, 14049-900 Ribeirao Preto, SP, Brazil.

Background: Despite strong association between epilepsy and psychiatric comorbidities, biological substrates are unknown. We have previously reported decreased mossy fiber sprouting in mesial temporal lobe epilepsy (MTLE) patients with psychosis and increased in those with major depression. Microtubule associated proteins (MAPs) are essentially involved in dendritic and synaptic sprouting. Read More

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Left atrium volume index is influenced by aortic stiffness and central pulse pressure in type 2 diabetes mellitus patients: a hemodynamic and echocardiographic study.

Med Sci Monit 2013 Mar 4;19:153-64. Epub 2013 Mar 4.

Department of Cardiology, Medical University of Lublin, Lublin, Poland.

Background: Left atrial volume index (LAVI) has recently emerged as a useful biomarker for risk stratification and risk monitoring in many clinical settings. Many hemodynamic factors such as preload and afterload have an effect on evaluating left atrium function. This study was performed to investigate the relationship between LAVI and aortic stiffness index (ASI) and selected markers characterizing hemodynamic state in patients with type 2 diabetes mellitus (DM2). Read More

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Phylogenetic and Biological Characterization of Fusarium oxysporum Isolates Associated with Onion in South Africa.

Plant Dis 2012 Sep;96(9):1250-1261

Department of Plant Pathology, Stellenbosch University, Private Bag X1, Matieland, 7600, South Africa.

Fusarium oxysporum f. sp. cepae causes Fusarium basal rot of onion, a disease of worldwide importance. Read More

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September 2012

Megalocytiviruses.

Viruses 2012 04 10;4(4):521-38. Epub 2012 Apr 10.

National Research Institute of Aquaculture, Fisheries Research Agency, Minamiise 519-0423, Japan.

The genus Megalocytivirus, represented by red sea bream iridovirus (RSIV), the first identified and one of the best characterized megalocytiviruses, Infectious spleen and kidney necrosis virus (ISKNV), the type species of the genus, and numerous other isolates, is the newest genus within the family Iridoviridae. Viruses within this genus are causative agents of severe disease accompanied by high mortality in multiple species of marine and freshwater fish. To date outbreaks of megalocytivirus-induced disease have occurred primarily in south-east Asia and Japan, but infections have been detected in Australia and North America following the importation of infected ornamental fish. Read More

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Gender-based differences in hemostatic responses.

Per Med 2012 Mar;9(2):191-199

Department of Pathology, Loyola University Medical Center, 2160 S. First Avenue, Maywood, IL 60153, USA.

Aim: Recent reports indicate increased mortality in women owing to cardiovascular diseases necessitating more gender-based studies. It is hypothesized that women have variable hemostatic responses to anticoagulant drugs.

Materials & Methods: The hemostatic responses in healthy males (n = 10) and females (n = 10) were evaluated by performing various assays in the presence of anticoagulant drugs. Read More

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Perioperative change in peripheral blood monocyte count may predict prognosis in patients with colorectal liver metastasis after hepatic resection.

J Surg Oncol 2012 Jul 9;106(1):31-5. Epub 2012 Jan 9.

Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.

Background: Prognostic value of perioperative change in peripheral blood leukocyte subset count of cancer patients have not been fully investigated. Therefore, we retrospectively investigated the relation between perioperative change in peripheral blood monocyte count and disease-free as well as overall survival after hepatic resection for colorectal liver metastasis (CRLM).

Methods: The subjects were 64 patients who underwent hepatic resection for CRLM between January 2000 and December 2008. Read More

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PIK3CA mutations and amplification in endometrioid endometrial carcinomas: relation to other genetic defects and clinicopathologic status of the tumors.

Hum Pathol 2011 Nov 29;42(11):1710-9. Epub 2011 Apr 29.

Endocrinology Department, The Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, 5 W.K. Roentgen Street, 02-781 Warsaw, Poland.

Alterations of the PIK3CA gene occur in endometrial carcinomas, but their role in the carcinogenesis of those malignancies is still poorly understood. In this study, PIK3CA mutations and amplification in 196 endometrioid endometrial carcinomas and 20 endometrial hyperplasias were assessed by single-strand conformation polymorphism (PCR-SSCP), sequencing, and quantitative polymerase chain reaction. Results were correlated with mutations in the PTEN, KRAS, and CTNNB1 genes and with the clinicopathologic parameters of the tumors. Read More

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November 2011