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Severe Preeclampsia is Associated with Functional and Structural Cardiac Alterations: A Case-control Study.

Z Geburtshilfe Neonatol 2021 Apr 9. Epub 2021 Apr 9.

Department of Cardiology, Pamukkale University, Denizli, Turkey.

Background: The aim of the current study is to compare electrocardiographic and echocardiographic changes in patients with severe preeclampsia (PE) and those with uncomplicated pregnancies.

Methods: This is a case-controlled prospective study consisting of 21 pregnant women with severe preeclampsia and a control group consisting of age- and gestational age-matched 24 healthy pregnant women. All patients underwent electrocardiographic and echocardiographic investigation. Read More

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Effects of low vs. high frequency local vibration on mild-moderate muscle spasticity: Ultrasonographical and functional evaluation in patients with multiple sclerosis.

Mult Scler Relat Disord 2021 Mar 31;51:102930. Epub 2021 Mar 31.

Hacettepe University, Faculty of Physical Therapy and Rehabilitation, 06100 Samanpazarı/Altındag, Ankara, Turkey. Electronic address:

Background: Local vibration (LV) is a physiotherapy application that aims to reduce spasticity. The study aimed to compare the effects of 50 Hz vs. 100 Hz LV on mild-moderate spasticity, functional performance and muscle architecture. Read More

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Discriminating cognitive motor dissociation from disorders of consciousness using structural MRI.

Neuroimage Clin 2021 Mar 29;30:102651. Epub 2021 Mar 29.

Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Electronic address:

An accurate evaluation and detection of awareness after a severe brain injury is crucial to a patient's diagnosis, therapy, and end-of-life decisions. Misdiagnosis is frequent as behavior-based assessments often overlook subtle signs of consciousness. This study aimed to identify brain MRI characteristics of patients with residual consciousness after a severe brain injury and to develop a simple MRI-based scoring system according to the findings. Read More

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A pioneering FreeSurfer volumetric study of a series of patients with mesial temporal lobe epilepsy and hippocampal sclerosis with comorbid depression.

Psychiatry Res Neuroimaging 2021 Mar 19;311:111281. Epub 2021 Mar 19.

Department of Neurology and Neurosurgery, Universidade Federal de São Paulo (UNIFESP), Pedro de Toledo Street, 650, 1st floor. Postal number: 04039-002 Vila Clementino, São Paulo, Brazil.

Depression is the most frequent psychiatric comorbidity in patients with mesial temporal lobe epilepsy (MTLE) and hippocampal sclerosis (HS). This study aimed to confirm whether patients with comorbid depression have different volumetric patterns on magnetic resonance imaging, analysing the influence of HS sides. Psychiatrists conducted semi-structured interviews with 75 patients, who were divided into non-depression group (NDG, n = 52) and depression group (DG, n = 23), and compared with 98 controls. Read More

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Beyond language impairment: Profiles of apathy in primary progressive aphasia.

Cortex 2021 Mar 16;139:73-85. Epub 2021 Mar 16.

The University of Sydney, Brain & Mind Centre, Sydney, NSW, Australia; The University of Sydney, School of Psychology, Sydney, NSW, Australia. Electronic address:

Primary progressive aphasia (PPA) is characterised by predominant language and communication impairment. However, behavioural changes, such as apathy, are increasingly recognised. Apathy is defined as a reduction in motivation and goal-directed behaviour. Read More

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Reinstatement of Item-Specific Contextual Details During Retrieval Supports Recombination-Related False Memories.

Neuroimage 2021 Apr 6:118033. Epub 2021 Apr 6.

Department of Psychology and Center for Brain Science, Harvard University.

Flexible retrieval mechanisms that allow us to infer relationships across events may also lead to memory errors or distortion when details of one event are misattributed to the related event. Here, we tested how making successful inferences alters representation of overlapping events, leading to false memories. Participants encoded overlapping associations ('AB' and 'BC'), each of which was superimposed on different indoor and outdoor scenes that were pre-exposed prior to associative learning. Read More

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Stairway to memory: left-hemispheric alpha dynamics index the progressive loading of items into a short-term store.

Neuroimage 2021 Apr 6:118024. Epub 2021 Apr 6.

College of Medicine, University of Nebraska Medical Center, Omaha, NE; Institute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE.

The encoding, maintenance, and subsequent retrieval of memories over short time intervals is an essential cognitive function. Load effects on the neural dynamics supporting the maintenance of short-term memories have been well studied, but experimental design limitations have hindered the study of similar effects during the encoding of information into online memory stores. Theoretically, the active encoding of complex visual stimuli into memory must also recruit neural resources in a manner that scales with memory load. Read More

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Gray matter volume in left intraparietal sulcus predicts longitudinal gains in subtraction skill in elementary school: Running title (5 words): Gray matter volume predicts subtraction.

Neuroimage 2021 Apr 6:118021. Epub 2021 Apr 6.

Department of Psychology and Human Development, Vanderbilt University, Nashville, Tennessee, USA.

Although behavioral studies show large improvements in arithmetic skills in elementary school, we do not know how brain structure supports math gains in typically developing children. While some correlational studies have investigated the concurrent association between math performance and brain structure, such as gray matter volume (GMV), longitudinal studies are needed to infer if there is a causal relation. Although discrepancies in the literature on the relation between GMV and math performance have been attributed to the different demands on quantity vs. Read More

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Int J Radiat Oncol Biol Phys 2021 Apr 6. Epub 2021 Apr 6.

Department of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus OH, USA. Electronic address:

Purpose: Cardiac radioablation (CRA) utilizing stereotactic body radiation therapy is gaining popularity as a non-invasive treatment for otherwise refractory ventricular arrhythmias. As radiation oncologists may be unaccustomed to the lexicon employed by cardiologists to describe the location of arrhythmogenic foci, a preliminary guide to cardiac-specific anatomy and orientation is needed to foster effective communication between the radiation oncologist and cardiology team.

Materials And Methods: ECG-gated and respiratory-gated CTs were acquired per institutional protocol. Read More

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Abdominal Aorta Bullet Embolism: Presentation and Management.

Ann Vasc Surg 2021 Apr 6. Epub 2021 Apr 6.

Department of Surgery, Broward Health Medical Center, Fort Lauderdale, FL, 33316.

Penetrating cardiac injury (PCI) secondary to a gunshot wound presents with several complications and a mortality rate of 94% before reaching the hospital. Current literature search reveals that embolism of bullet fragments after gunshot wounds are exceptionally rare. Additionally, no reported case was found regarding bullet embolism following left atrium penetration at the time of this case report. Read More

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Unmasking the coronary-subclavian steal syndrome: the culprit lies in the subclavian artery. A report of a case and review of the literature.

Ann Vasc Surg 2021 Apr 6. Epub 2021 Apr 6.

Departments of Vascular Surgery. Electronic address:

The coronary-subclavian steal syndrome (CSSS) is a hemodynamic phenomenon in which a subclavian artery stenosis or occlusion impairs blood flow at the origin of the left internal mammary artery (LIMA) used for coronary artery bypass grafting (CABG), causing retrograde blood flow and thus provoking symptoms of cardiac ischemia and its complications. Once considered the gold-standard operation of choice, open revascularization has now been abandoned as a first line treatment and replaced by endovascular techniques. In all cases, detailed and oriented physical examination in combination with further imaging in high clinical suspicion for CSSS remains the sine qua non of the preoperative examination of the patient. Read More

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Anisotropic Conductive Reduced Graphene Oxide/Silk Matrices Promote Post-Infarction Myocardial Function by Restoring Electrical Integrity.

Acta Biomater 2021 Apr 6. Epub 2021 Apr 6.

The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, International Joint Laboratory for Micro/Nano Manufacturing and Measurement Technology, Xi'an Jiaotong University, Xi'an 710049, Shannxi, P.R. China. Electronic address:

Myocardial infarction (MI) remains the leading cause of death globally, often leading to impaired cardiac function and pathological myocardial microenvironment. Electrical conduction abnormalities of the infarcted myocardium not only induce adverse myocardial remodeling but also prevent tissue repair. Restoring the myocardial electrical integrity, particularly the anisotropic electrical signal propagation within the injured area after infarction is crucial for an effective function recovery. Read More

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Rhesus macaques build new social connections after a natural disaster.

Curr Biol 2021 Apr 8. Epub 2021 Apr 8.

Centre for Research in Animal Behaviour, University of Exeter, Exeter, UK.

Climate change is increasing the frequency and intensity of weather-related disasters such as hurricanes, wildfires, floods, and droughts. Understanding resilience and vulnerability to these intense stressors and their aftermath could reveal adaptations to extreme environmental change. In 2017, Puerto Rico suffered its worst natural disaster, Hurricane Maria, which left 3,000 dead and provoked a mental health crisis. Read More

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Neural Representations of Task Context and Temporal Order During Action Sequence Execution.

Top Cogn Sci 2021 Apr 9. Epub 2021 Apr 9.

Department of Experimental Psychology, Ghent University.

Routine action sequences can share a great deal of similarity in terms of their stimulus response mappings. As a consequence, their correct execution relies crucially on the ability to preserve contextual and temporal information. However, there are few empirical studies on the neural mechanism and the brain areas maintaining such information. Read More

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Large-Scale Phenomic and Genomic Analysis of Brain Asymmetrical Skew.

Cereb Cortex 2021 Apr 9. Epub 2021 Apr 9.

Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen 6525 XD, The Netherlands.

The human cerebral hemispheres show a left-right asymmetrical torque pattern, which has been claimed to be absent in chimpanzees. The functional significance and developmental mechanisms are unknown. Here, we carried out the largest-ever analysis of global brain shape asymmetry in magnetic resonance imaging data. Read More

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Left Atrial Diameter and Atrial Ectopic Burden in Patients with Embolic Stroke of Undetermined Source: Risk Stratification of Atrial Fibrillation with Insertable Cardiac Monitor Analysis.

J Clin Neurol 2021 Apr;17(2):213-219

Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Background And Purpose: An insertable cardiac monitor (ICM) has been demonstrated to be a useful tool for detecting subclinical atrial fibrillation (AF) in patients with embolic stroke of undetermined source (ESUS). This study aimed to identify the clinical predictors of AF in ESUS patients with ICMs.

Methods: We retrospectively selected consecutive patients with an ICM implanted for AF detection following ESUS. Read More

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Association between oral contraceptive use and incident heart failure.

ESC Heart Fail 2021 Apr 9. Epub 2021 Apr 9.

Department of Cardiology, Guangdong Provincial People's Hospital, Guangdong Cardiovascular Institute, Guangdong Academy of Medical Sciences, 106 Zhongshan 2nd Road, Guangzhou, 510080, China.

Aims: Oral contraceptives (OCs) are widely used in women of reproductive age, but their influences on heart failure (HF) development have yet to be reported. This study was performed to assess HF risk associated with OC use.

Methods And Results: We studied women participating in the Multi-Ethnic Study of Atherosclerosis with available data on OC use. Read More

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Novel dilated cardiomyopathy associated to Calreticulin and Myo7A gene mutation in Usher syndrome.

ESC Heart Fail 2021 Apr 9. Epub 2021 Apr 9.

MEBIC Consortium, San Raffaele Open University and IRCCS San Raffaele Pisana, Rome, Italy.

We report a novel cardiomyopathy associated to Usher syndrome and related to combined mutation of MYO7A and Calreticulin genes. A 37-year-old man with deafness and vision impairment because of retinitis pigmentosa since childhood and a MYO7A gene mutation suggesting Usher syndrome, developed a dilated cardiomyopathy with ventricular tachyarrhythmias and recurrent syncope. At magnetic resonance cardiomyopathy was characterized by left ventricular dilatation with hypo-contractility and mitral prolapse with valve regurgitation. Read More

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Isolated Left Bundle Branch Block in the Young: Case Reports and Review of Literature.

Pacing Clin Electrophysiol 2021 Apr 9. Epub 2021 Apr 9.

Center for Arrhythmia Care, Heart & Vascular Center, Pritzker School of Medicine of the University of Chicago, Chicago, IL, USA.

Isolated left bundle branch block (LBBB) aberrancy is exceedingly rare in the young and its clinical and genetic determinants remain poorly characterized. Furthermore, there is conflicting data on its natural history in the pediatric age group patients. We report the rare phenotype of isolated typical LBBB aberrancy in two healthy children, one of whom carried a likely pathogenic mutation in the coding exon 1 of NKX2-5 (p. Read More

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Corporal Punishment and Elevated Neural Response to Threat in Children.

Child Dev 2021 Apr 9. Epub 2021 Apr 9.

Harvard University.

Spanking remains common around the world, despite evidence linking corporal punishment to detrimental child outcomes. This study tested whether children (M  = 11.60) who were spanked (N = 40) exhibited altered neural function in response to stimuli that suggest the presence of an environmental threat compared to children who were not spanked (N = 107). Read More

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Effects of Low-frequency Repetitive Transcranial Magnetic Stimulation on Focal Hand Dystonia: A Case Report.

Tokai J Exp Clin Med 2021 Apr 20;46(1):44-50. Epub 2021 Apr 20.

Department of Rehabilitation Medicine, Tokai University Hachioji Hospital, 1838 Ishikawa-machi, Hachioji, Tokyo 192-0032, Japan.

A 40-year-old female patient with no medical history or family history of dystonia showed no abnormalities on cranial MRI. However, flexions and extensions were poor during the right arm and elbow movements, and tremors were observed during the finger separation movement. The tremors reduced when the left hand was placed on the right shoulder. Read More

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A surgical Case of Synchronous Multiple Primary Lung Cancers with Small Cell Carcinoma and Squamous Cell Carcinoma.

Tokai J Exp Clin Med 2021 Apr 20;46(1):29-32. Epub 2021 Apr 20.

Division of Thoracic Surgery, Tokai University Oiso Hospital, 21-1 Gakkyo, Oiso, Kanagawa 259-0198, Japan.

The incidence of synchronous multiple primary lung cancers has increased in recent years, however, there are few reports of cases involving small cell carcinoma. A 72-year-old man was referred to our department because of an abnormal shadow on chest radiography. He was receiving treatment for pulmonary fibrosis, emphysema, rheumatoid arthritis, and prostate cancer. Read More

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Localized Maxillary Sinus Papilloma: Management of Incidental Lesion.

Tokai J Exp Clin Med 2021 Apr 20;46(1):17-21. Epub 2021 Apr 20.

Department of Otolaryngology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.

Most maxillary sinus papillomas are confirmed when they have extended beyond the nasal cavity and are rarely found while localized in the maxillary sinus. We experienced two cases of localized papilloma in the maxillary sinus. Case 1 was a 69-year-old man with a localized left maxillary sinus lesion detected during a routine imaging examination. Read More

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Selenium, Selenoproteins, and Heart Failure: Current Knowledge and Future Perspective.

Curr Heart Fail Rep 2021 Apr 9. Epub 2021 Apr 9.

Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Purpose Of Review: (Mal-)nutrition of micronutrients, like selenium, has great impact on the human heart and improper micronutrient intake was observed in 30-50% of patients with heart failure. Low selenium levels have been reported in Europe and Asia and thought to be causal for Keshan disease. Selenium is an essential micronutrient that is needed for enzymatic activity of the 25 so-called selenoproteins, which have a broad range of activities. Read More

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Large-volume cell-free and concentrated ascites reinfusion therapy improves venous flow in patients with liver cirrhosis.

J Med Ultrason (2001) 2021 Apr 9. Epub 2021 Apr 9.

Ascites Treatment Center, Kanamecho Hospital, 1-11-13 Kanamecho, Toshima-ku, Tokyo, 171-0043, Japan.

Purpose: Hemodynamic change after total paracentesis was investigated because it might lead to various complications. Although cell-free and concentrated ascites reinfusion therapy (CART) is safer and more effective than total paracentesis in theory, hemodynamic change after CART has been never reported. And previous studies did not mention hemodynamics of the venous system. Read More

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Sexual Dimorphism in Hemispheric Processing of Faces in Humans: A Meta-Analysis of 817 Cases.

Soc Cogn Affect Neurosci 2021 Apr 9. Epub 2021 Apr 9.

Neuro-Mi Center for Neuroscience, Department of Psychology, University of Milano-Bicocca, 20162 Milan, Italy.

A well-established neuroimaging literature predicts a right-sided asymmetry in the activation of face-devoted areas such as the fusiform gyrus (FG) and its resulting M/N170 response during face processing. However, the face-related response sometimes appears to be bihemispheric. A few studies have argued that bilaterality depended on the sex composition of the sample. Read More

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Goal-directed Fluid Therapy Versus Conventional Fluid Therapy During Craniotomy and Clipping of Cerebral Aneurysm: A Prospective Randomized Controlled Trial.

J Neurosurg Anesthesiol 2021 Apr 8. Epub 2021 Apr 8.

Departments of Anaesthesia and Intensive Care Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: Fluid imbalance is common after aneurysmal subarachnoid hemorrhage and negatively impacts clinical outcomes. We compared intraoperative goal-directed fluid therapy (GDFT) using left ventricular outflow tract velocity time integral (LVOT-VTI) measured by transesophageal echocardiography with central venous pressure (CVP)-guided fluid therapy during aneurysm clipping in aneurysmal subarachnoid hemorrhage patients.

Methods: Fifty adults scheduled for urgent craniotomy for aneurysm clipping were randomly allocated to 2 groups: group G (n=25) received GDFT guided by LVOT-VTI and group C (n=25) received CVP-guided fluid management. Read More

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Evaluation of the influence of mandibular condylar contour, height, and asymmetry in subjects with myalgia presenting with or without clicking among south coastal Karnataka population - A descriptive cross-sectional study.

J Indian Prosthodont Soc 2021 Jan-Mar;21(1):81-87

Department of Prosthodontics and Crown and Bridge, Nitte (Deemed to be University), AB Shetty Memorial Institute of Dental Sciences, Mangalore, Karnataka, India.

Aim: The purpose was to evaluate the morphological variations of the condyle in patients presenting with myalgia associated with and without clicking of temporomandibular joint (TMJ) and its possible effect on the contour and height.

Setting And Design: Cross sectional study.

Material And Methods: A total of 60 patients comprising of 20 patients with myalgia, 20 patients with myalgia associated with clicking of TMJ, and a control group of 20 patients without any signs and symptoms of temporomandibular disorder were selected for purpose of the study. Read More

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Unraveling a cephalalgic quagmire from a cavern to a cave.

J Postgrad Med 2021 Apr 8. Epub 2021 Apr 8.

Department of Neurosurgery, Chettinad Academy of Research and Education, Chennai, Tamil Nadu, India.

Headache in women in their late forties can be primary or secondary. We report a 48-year-old female with chronic slowly progressive left temporal headache for 1 year. She also had ipsilateral eye pain and facial numbness for 1 month, with restricted abduction in the left eye and diplopia. Read More

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Could pure agraphia be the only sign of stroke? Lessons from two case reports.

J Postgrad Med 2021 Apr 8. Epub 2021 Apr 8.

IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy.

Agraphia is defined as the disruption of the previously intact writing skills due to an acquired brain damage. Stroke remains the most common cause of language impairment; however, writing disorders, including agraphia, are underestimated in patients with stroke. In this regard, we report two patients presenting with pure agraphia as an early symptom of stroke. Read More

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