61,960 results match your criteria "pel 05"

Southern Mediterranean coast pollution: Long-term assessment and evolution of PAH pollutants in Monastir Bay (Tunisia).

Mar Pollut Bull 2021 Apr 7;167:112268. Epub 2021 Apr 7.

Laboratory of Georessources, technopole of Borj Cedria, 273, University Carthage, Soliman 8020, Tunisia.

In order to evaluate the long-term pollution level(s) of Monastir Bay (Tunisian-Mediterranean coastal area), four sediment cores were collected from the meeting points between the main local streams and the marine environment and investigated. Macroscopic observations and granulometric and chemical compositions showed that this Bay received heterogeneous materials. The distribution of 15 total PAH (priority pollutants) concentrations in different levels of core sediments ranged from 222 to 2992 μg kg. Read More

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Antiviral zinc oxide nanoparticles mediated by hesperidin and in silico comparison study between antiviral phenolics as anti-SARS-CoV-2.

Colloids Surf B Biointerfaces 2021 Mar 26;203:111724. Epub 2021 Mar 26.

Department of Phytochemistry and Plant Systematics, Pharmaceutical Division, National Research Centre, Dokki, Cairo, Egypt. Electronic address:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused the coronavirus (COVID-19), is the virus responsible for over 69,613,607 million infections and over 1,582,966 deaths worldwide. All treatment measures and protocols were considered to be supportive only and not curative. During this current coronavirus pandemic, searching for pharmaceutical or traditional complementary and integrative medicine to assist with prevention, treatment, and recovery has been advantageous. Read More

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Prevalence of at-risk hyperandrogenism by age and race/ethnicity among females in the United States using NHANES III.

Eur J Obstet Gynecol Reprod Biol 2021 Mar 26;260:189-197. Epub 2021 Mar 26.

Office of Research Resources, Biostatistics and Epidemiology Consulting Lab, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, USA; Division of Biostatistics & Epidemiology, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, USA. Electronic address:

Objective: Hyperandrogenism in females leads to multiple endocrine and metabolic disorders including polycystic ovary syndrome (PCOS) that yields adverse health outcomes across all ages. We sought to estimate the prevalence of hyperandrogenemia and at-risk hyperandrogenism among the US females of different age groups, racial/ethnic, and metabolic characteristics.

Materials And Methods: A retrospective population-based cross-sectional study of females 6 years or older having serum testosterone measures using the National Health and Nutrition Examination Surveys, 2013-2016 was conducted. Read More

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The endemic Chamaecytisus albidus is nodulated by symbiovar genistearum of Bradyrhizobium in the Moroccan Maamora Forest.

Syst Appl Microbiol 2021 Mar 26;44(3):126197. Epub 2021 Mar 26.

Centre de Biotechnologies Végétale et Microbienne, Biodiversité et Environnement, Faculté des Sciences, Université Mohammed V de Rabat, 4, Avenue Ibn Battouta, Rabat, Morocco. Electronic address:

Out of 54 isolates from root nodules of the Moroccan-endemic Chamaecytisus albidus plants growing in soils from the Maamora cork oak forest, 44 isolates formed nodules when used to infect their original host plant. A phenotypic analysis showed the metabolic diversity of the strains that used different carbohydrates and amino acids as sole carbon and nitrogen sources. The isolates grew on media with pH values ranging from 6 to 8. Read More

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Model comparison and quantification of nitrous oxide emission and mitigation potential from maize and wheat fields at a global scale.

Sci Total Environ 2021 Mar 24;782:146696. Epub 2021 Mar 24.

Institute of Biological & Environmental Sciences, School of Biological Sciences, University of Aberdeen, Cruickshank Building, St. Machar Drive, Aberdeen AB24 3UU, UK.

Maize and wheat are major cereals that contribute two-thirds of the food energy intake globally. The two crops consume about 35% of the nitrogen (N) fertilizer used in agriculture and thereby contribute to fertilizer-induced nitrous oxide (NO) emissions. Thus, estimation of spatially disaggregated NO emissions from maize and wheat fields on a global scale could be useful for identifying emission and mitigation hotspots. Read More

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Az achondroplasia a fogszabályozás szemszögéből.

Orv Hetil 2021 Apr 10;162(17):683-688. Epub 2021 Apr 10.

3 Heim Pál Országos Gyermekgyógyászati Intézet, Alvásdiagnosztikai és Terápiás Labor, Budapest.

Összefoglaló. Az achondroplasia kialakulásáért az FGFR3-gén mutációja tehető felelőssé, mely a porc növekedési lemezében található chondrocyták érésében okoz zavart. Az esetbemutatásban szereplő lánygyermeknél a születést követő első hónapban a klinikai, laboratóriumi és röntgenvizsgálatok alapján achondroplasia igazolódott. Read More

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Exploration of spatial-temporal varying impacts on COVID-19 cumulative case in Texas using geographically weighted regression (GWR).

Environ Sci Pollut Res Int 2021 Apr 10. Epub 2021 Apr 10.

School of Resource and Environmental Science, Wuhan University, 129 Luoyu Rd., Wuhan, 430079, Hubei, China.

Since COVID-19 is extremely threatening to human health, it is significant to determine its impact factors to curb the virus spread. To tackle the complexity of COVID-19 expansion on a spatial-temporal scale, this research appropriately analyzed the spatial-temporal heterogeneity at the county-level in Texas. First, the impact factors of COVID-19 are captured on social, economic, and environmental multiple facets, and the communality is extracted through principal component analysis (PCA). Read More

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Predicting the relative oral bioavailability of naturally occurring As, Cd and Pb from in vitro bioaccessibility measurement: implications for human soil ingestion exposure assessment.

Environ Geochem Health 2021 Apr 10. Epub 2021 Apr 10.

Department of Earth Sciences, Faculty of Experimental Sciences, University of Huelva, Campus de El Carmen, 21071, Huelva, Spain.

Chestnut soils developed over mineralized areas of southwestern Spain are characterized by high baseline concentrations of geogenic trace elements, notably Pb (up to 14,562 mg kg), As (up to 346 mg kg) and Cd (up to 319 mg kg), which could pose an unacceptable risk to the health of the hand-harvest workers who are being exposed to surface soil by incidental ingestion and dermal contact. Oral bioaccessibility, as determined by simulating the human digestion process in a test-tube environment (Unified BARGE Method), followed the increasing order of As (3.1%) < Pb (21. Read More

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Diacylglycerol kinase α inhibition cooperates with PD-1-targeted therapies to restore the T cell activation program.

Cancer Immunol Immunother 2021 Apr 10. Epub 2021 Apr 10.

Immunology and Oncology, Centro Nacional de Biotecnología-CSIC, Madrid, Spain.

Background: Antibody-based therapies blocking the programmed cell death-1/ligand-1 (PD-1/PD-L1) axis have provided unprecedent clinical success in cancer treatment. Acquired resistance, however, frequently occurs, commonly associated with the upregulation of additional inhibitory molecules. Diacylglycerol kinase (DGK) α limits the extent of Ras activation in response to antigen recognition, and its upregulation facilitates hypofunctional, exhausted T cell states. Read More

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Uncertainty in protein-ligand binding constants: asymmetric confidence intervals versus standard errors.

Eur Biophys J 2021 Apr 10. Epub 2021 Apr 10.

Department of Biothermodynamics and Drug Design, Institute of Biotechnology, Life Sciences Center, Vilnius University, Saulėtekio 7, 10257, Vilnius, Lithuania.

Equilibrium binding constants (K) between chemical compounds and target proteins or between interacting proteins provide a quantitative understanding of biological interaction mechanisms. Reported uncertainties of measured experimental parameters are critical for decision-making in many scientific areas, e.g. Read More

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Current capsid assembly models of icosahedral nucleocytoviricota viruses.

Adv Virus Res 2020 5;108:275-313. Epub 2020 Oct 5.

Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas, United States. Electronic address:

Nucleocytoviricota viruses (NCVs) belong to a newly established phylum originally grouped as Nucleocytoplasmic large DNA viruses. NCVs are unique because of their large and complicated genomes that contain cellular genes with homologs from all kingdoms of life, raising intensive debates on their evolutional origins. Many NCVs pack their genomes inside massive icosahedral capsids assembled from thousands of proteins. Read More

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October 2020

Risk of early complication following anterior vertebral body tethering for idiopathic scoliosis.

Spine Deform 2021 Apr 9. Epub 2021 Apr 9.

Division of Orthopaedic Surgery, Department of Surgery, IWK Health Center, 5850 University Avenue, PO Box 9700, Halifax, NS, B3K-6R8, Canada.

Purpose: The purpose of this study was to determine peri-operative morbidity associated with anterior vertebral body tethering (aVBT) for idiopathic scoliosis.

Method: Of 175 patients treated with aVBT, 120 patients had 2 year follow up and were included in this study. Prospectively collected clinical and radiographic data was analyzed retrospectively. Read More

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Influences of Intermittent Pneumatic Compression Therapy on Edema and Postoperative Patient's Satisfaction After Lipoabdominoplasty.

Aesthetic Plast Surg 2021 Apr 9. Epub 2021 Apr 9.

Department of Physical Therapy, New Kasr El-Aini Teaching Hospital, Faculty of Medicine, Cairo University, Cairo, Egypt.

Background: Lipoabdominoplasty (LABP) is a frequently performed surgical procedure in the field of plastic surgery that often requires physical therapy in order to minimize postoperative complications, augment the postoperative outcomes, and enhance recovery. Intermittent pneumatic compression therapy (IPCT) is a physical therapy modality that may be used in the management of LABP population. This study aimed to assess the influences of intermittent pneumatic compression therapy on the resolution of edema and improvement in postoperative patient satisfaction following LABP. Read More

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Coronal and axial alignment relationship in Caucasian patients with osteoarthritis of the knee.

Sci Rep 2021 Apr 9;11(1):7836. Epub 2021 Apr 9.

Department of Orthopaedic Surgery and Traumatology, Hospital Clínico Universitario Virgen de la Arrixaca, Ctra. Madrid-Cartagena, s/n, El Palmar, 30120, Murcia, Spain.

Individualized pre-operative assessment of the patterns of the lower extremity anatomy and deformities in patients undergoing total knee arthroplasty seems essential for a successful surgery. In the present study, we investigated the relationship among the coronal alignment and the rotational profile of the lower extremities in the Caucasian population with end-stage knee osteoarthritis. We conducted a prospective study of 385 knees that underwent a pre-operative three-dimensional computed tomography-based model. Read More

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Mature Andean forests as globally important carbon sinks and future carbon refuges.

Nat Commun 2021 Apr 9;12(1):2138. Epub 2021 Apr 9.

Biology Department, University of Miami, Coral Gables, FL, USA.

It is largely unknown how South America's Andean forests affect the global carbon cycle, and thus regulate climate change. Here, we measure aboveground carbon dynamics over the past two decades in 119 monitoring plots spanning a range of >3000 m elevation across the subtropical and tropical Andes. Our results show that Andean forests act as strong sinks for aboveground carbon (0. Read More

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Effects of microorganism-mediated inoculants on humification processes and phosphorus dynamics during the aerobic composting of swine manure.

J Hazard Mater 2021 Mar 25;416:125738. Epub 2021 Mar 25.

Department of Civil and Environmental Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.

There is significant interest in the treatment of swine manure, which is a hazardous biowaste and a source of pathogenic contamination. This work investigated the effects of microorganism-mediated inoculants (MMIs) on nutrient flows related to humification or phosphorus (P) dynamics during the aerobic composting of swine manure. The impact of MMIs on microbe succession was also evaluated. Read More

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New regimens of benznidazole monotherapy and in combination with fosravuconazole for treatment of Chagas disease (BENDITA): a phase 2, double-blind, randomised trial.

Lancet Infect Dis 2021 Apr 6. Epub 2021 Apr 6.

DNDi Latin America, Rio de Janeiro, Brazil; Epidemiology and Public Health Research Centre, CONICET, Buenos Aires, Argentina. Electronic address:

Background: Current treatment for Chagas disease with the only available drugs, benznidazole or nifurtimox, has substantial limitations, including long treatment duration and safety and tolerability concerns. We aimed to evaluate the efficacy and safety of new benznidazole monotherapy regimens and combinations with fosravuconazole, in the treatment of Chagas disease.

Methods: We did a double-blind, double-dummy, phase 2, multicentre, randomised trial in three outpatient units in Bolivia. Read More

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Microbiome research in general and business newspapers: How many microbiome articles are published and which study designs make the news the most?

PLoS One 2021 9;16(4):e0249835. Epub 2021 Apr 9.

Department of Communication, Pompeu Fabra University, Barcelona, Spain.

The microbiome is a matter of interest for science, consumers and business. Our objective is to quantify that interest in academic journals and newspapers, both quantitatively and by study design. We calculated the number of articles on the microbiome from the total number of biomedicine articles featured in both PubMed and Spanish science news agency SINC, from 2008 to 2018. Read More

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Impact of Cooking Preparation on Digestion of Eggs Simulating Some Gastrointestinal Alterations in Elders.

J Agric Food Chem 2021 Apr 9. Epub 2021 Apr 9.

Instituto Universitario de Ingeniería de Alimentos para el Desarrollo, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain.

This study aimed to assess the impact of the cooking process of eggs (hard-boiled, poached, and omelet) on nutrients digestibility and vitamins A and D3 bioaccessibility under elderly gastrointestinal (GI) conditions. Three elderly digestion models were mimicked: oral (E1); oral and gastric (E2); and oral, gastric, and intestinal (E3), and a healthy adult model (C). Proteolysis extent reduced after digestion of omelet under the E3 model ( < 0. Read More

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Association between Heart Failure and Clinical Prognosis in Patients with Acute Ischemic Stroke: A Retrospective Cohort Study.

J Clin Neurol 2021 Apr;17(2):200-205

School of Medicine, Universidad de la Sabana, Chía, Colombia.

Background And Purpose: Ischemic stroke is a common cause of death worldwide. In clinical practice it is observed that many individuals who have experienced an ischemic stroke also suffer from simultaneous comorbidities such as heart failure, which could be directly associated with a worse clinical prognosis. Therefore, this study analyzed outcomes in terms of the severity of the event, inhospital mortality, duration of hospital stay, and inhospital recurrence of the episode, in order to determine the implications resulting from the presentation of both pathologies. Read More

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Direct oral anticoagulants in chronic thromboembolic pulmonary hypertension.

J Thromb Thrombolysis 2021 Apr 9. Epub 2021 Apr 9.

Division of Pulmonary and Critical Care Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA.

Chronic thromboembolic pulmonary hypertension (CTEPH) represents the later stage consequence of at least one or more unresolved episodes of acute pulmonary embolism; thus, indefinite anticoagulation is strongly recommended by current practice guidelines. Historically, vitamin K antagonists have been widely used in these patients. However, recent data indicate a shift toward direct oral anticoagulants (DOACs), despite lack of data on the safety and efficacy in this patient population. Read More

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EnvRtype: a software to interplay enviromics and quantitative genomics in agriculture.

G3 (Bethesda) 2021 Feb 6. Epub 2021 Feb 6.

Department of Genetics, 'Luiz de Queiroz' Agriculture College, University of São Paulo, São Paulo, Brazil.

Envirotyping is an essential technique used to unfold the nongenetic drivers associated with the phenotypic adaptation of living organisms. Here, we introduce the EnvRtype R package, a novel toolkit developed to interplay large-scale envirotyping data (enviromics) into quantitative genomics. To start a user-friendly envirotyping pipeline, this package offers: (1) remote sensing tools for collecting (get_weather and extract_GIS functions) and processing ecophysiological variables (processWTH function) from raw environmental data at single locations or worldwide; (2) environmental characterization by typing environments and profiling descriptors of environmental quality (env_typing function), in addition to gathering environmental covariables as quantitative descriptors for predictive purposes (W_matrix function); and (3) identification of environmental similarity that can be used as an enviromic-based kernel (env_typing function) in whole-genome prediction (GP), aimed at increasing ecophysiological knowledge in genomic best-unbiased predictions (GBLUP) and emulating reaction norm effects (get_kernel and kernel_model functions). Read More

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February 2021

"Se extraña todo:" Family separation and reunification experiences among unaccompanied adolescent migrants from Central America.

New Dir Child Adolesc Dev 2021 Apr 9. Epub 2021 Apr 9.

Department of Clinical Psychology, Palo Alto University, Palo Alto, California, USA.

There has been a record surge of unaccompanied immigrant minors (UAMs) entering the United States, with 86% of those apprehended at the US-Mexico border originating from the Central American countries of El Salvador, Guatemala, and Honduras. A majority of immigrant children are separated from either one or both parents at various points during the migration process. Although average separations last 4 or more years, and may be deeply distressing, there is little research on family separations among Central American UAMs. Read More

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A Survey of Bluetongue Infection and Associated Risk Factors among the One-Humped Camel () in Gadarif State, Eastern Sudan.

Vet Med Int 2021 24;2021:6613217. Epub 2021 Mar 24.

Central Veterinary Research Laboratory (CVRL), Animal Resources Research Corporation (ARRC), P.O. Box 8067, El Amarat, Khartoum, Sudan.

Bluetongue (BT) is an infectious, noncontagious, vector-borne viral disease that affects wild and domestic ruminants transmitted by spp. A cross-sectional study was carried out during the period 2016-2017 in Gadarif state. A total of 276 sera samples were collected from camels in six localities of Gadarif state, eastern Sudan, to investigate bluetongue virus (BTV) seroprevalence and associated risk factors of BTV infection including age, sex, breed, locality, and ecology of the region. Read More

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Artificial intelligence for early detection of pancreatic adenocarcinoma: The future is promising.

World J Gastroenterol 2021 Apr;27(13):1283-1295

Department of Gastroenterology and Nutrition, Geisinger Medical Center, Danville, PA 17822, United States.

Pancreatic ductal adenocarcinoma (PDAC) is a worldwide public health concern. Despite extensive research efforts toward improving diagnosis and treatment, the 5-year survival rate at best is approximately 15%. This dismal figure can be attributed to a variety of factors including lack of adequate screening methods, late symptom onset, and treatment resistance. Read More

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Unveiling the role of novel biogenic functionalized CuFe hybrid nanocomposites in boosting anticancer, antimicrobial and biosorption activities.

Sci Rep 2021 Apr 8;11(1):7790. Epub 2021 Apr 8.

Environmental Biotechnology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), City of Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City, Alexandria, 21934, Egypt.

The quest for eco-friendly and biocompatible nanoparticles (NPs) is an urgent issue in the agenda of the scientific community and applied technology, which compressing synthesis routes. For the first time, a simple route for the biosynthesis of functionalized CuFe-hybrid nanocomposites (FCFNCs) was achieved using Streptomyces cyaneofuscatus through a simultaneous bioreduction strategy of Cu and Fe salts. The suitability of FCFNCs was evaluated medically and environmentally as an anticancer agent, antimicrobial agent and dye bio-sorbent. Read More

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Adolescent fluoxetine treatment mediates a persistent anxiety-like outcome in female C57BL/6 mice that is ameliorated by fluoxetine re-exposure in adulthood.

Sci Rep 2021 Apr 8;11(1):7758. Epub 2021 Apr 8.

Department of Psychology, The University of Texas at El Paso, 500 West University Avenue, El Paso, TX, 79968, USA.

The objective of this study was to evaluate whether juvenile fluoxetine (FLX) exposure induces long-term changes in baseline responses to anxiety-inducing environments, and if so, whether its re-exposure in adulthood would ameliorate this anxiety-like phenotype. An additional goal was to assess the impact of adolescent FLX pretreatment, and its re-exposure in adulthood, on serotonin transporters (5-HTT) and brain-derived-neurotrophic-factor (BDNF)-related signaling markers (TrkB-ERK1/2-CREB-proBDNF-mBDNF) within the hippocampus and prefrontal cortex. To do this, female C57BL/6 mice were exposed to FLX in drinking water during postnatal-days (PD) 35-49. Read More

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Limnological response from high-altitude wetlands to the water supply in the Andean Altiplano.

Sci Rep 2021 Apr 8;11(1):7681. Epub 2021 Apr 8.

Departamento de Biología, Facultad de Ciencias, Universidad de Tarapacá, Av. 18 de Septiembre 2222, Arica, Chile.

The Andean Altiplano-Puna is located at an elevation of approximately 4000 m.a.s. Read More

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[Neonatal-onset Niemann-Pick type C disease with COVID-19 infection].

An Pediatr (Barc) 2021 Mar 4. Epub 2021 Mar 4.

Hospital Clínico Universitario Lozano Blesa, Zaragoza, España; Facultad de Medicina, Universidad de Zaragoza, España; Instituto Investigación Sanitaria Aragón (IIS Aragón), España; Red de Salud Materno-infantil y del Desarrollo (SAMID), RETICS financiada por el the PN I+D+I 2018-2021, España.

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Cognitive emotion regulation questionnaire: Psychometric properties of the Tunisian version.

Encephale 2021 Apr 5. Epub 2021 Apr 5.

Laboratory of Psychology of Pays de la Loire (EA 4638), 5 bis, boulevard Lavoisier, 49045 Angers cedex 01, France.

Objectives: This study investigated the psychometric properties of the Cognitive Emotion Regulation Questionnaire in a Tunisian Arabic-Speaking population.

Method: The CERQ original version was translated and back-translated and then administrated to 360 participants. Afterwards, using the explanatory and confirmatory factor analysis, we studied the latent factor structure for CERQ. Read More

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