Our environment is contaminated by multiple pesticide residues whose long-term impact on health is subject to debate and concern. In order to mimic this chronic low-noise exposure, we treated transgenic mice model of Alzheimer's disease, with a cocktail of 3 fungicides (cyprodinil, mepanipyrim and pyrimethanil) at the regulatory dose of 0.1 ?g / L, present in drinking water.
Our results showed that chronic exposure to fungicides, even at very low doses, exacerbates markers of Alzheimer's disease such as amyloid deposits, inflammation and neuronal cell death.
Environ Health Perspect 2020 Jan 15;128(1):17011. Epub 2020 Jan 15.
MMDN, University of Montpellier, EPHE, INSERM, Montpellier, France.
Download full-text PDF