International J. of Healthcare and Biomedical Research
International J. of Healthcare and Biomedical Research, Volume: 04, Issue: 03, April 2016, 72 - 77
Background: The upper urinary tract urothelial carcinoma specially squamous cell type is a rare entity. It is associated with
chronic renal stone and infection which conceals the clinical diagnosis in the majority of the cases. We attempt to identify factors
associated with this malignancy along with clinicopathological characteristics and prognosis.
Material & methods : The nephrectomy specimens resected for renal malignancy and diagnosed as squamous cell carcinoma
(SCC) were reviewed retrospectively over a period of five years. Patient pertinent clinical , imaging , laboratory , and
histopathological information were analyzed.
Result : Total 36 nephrectomy specimens with renal malignancies were received. The incidence of SCC was found to be 16.6%
(6/36). In all the patients this carcinoma was associated with nephrolithiasis of long duration and pyelonephritis. The median
survival time was 4.6 months. Imaging studies diagnosed only one case which underwent radical nephrectomy with median
survival of 14 months. Poor response to surgery, radiotherapy, and chemotherapy resulted in a short survival.
Conclusion: The subtle presentation of this renal malignancy when associated with renal calculi and infection often delay the
early diagnosis leading to poor prognosis. Therefore, high index of suspicion by clinician and early imaging and laboratory
studies are required in patients with long duration of renal stone to detect associated renal malignancy.