Tumor proliferative and suppressive role of semaphorins


In this review tumor proliferative and suppressive role of a group of proteins called semaphorins and some therapeutic avenues have been discussed


It is going to help find drug targets for treatment of cancer.

Author Comments

ishtiaque ahammad
ishtiaque ahammad
National Institute of Biotechnology
Scientific Officer
Bioinformatics, Systems Biology
Dhaka | Bangladesh
This was a very long work where so many details about semaphorin mediated pathways that leads to cancer progression had to be absorbed and be presented in a meaningful way.ishtiaque ahammad

A comprehensive review of tumor proliferative and suppressive role of semaphorins and therapeutic approaches

Biophysical Reviews

Semaphorins have been traditionally known as axon guidance proteins that negatively regulate axonal growth. However, in the past couple of decades, their versatile role in so many other biological processes has come to prominence as well. One such example is their role in cancer. In this review article, the focus was on the tumor proliferative and tumor suppressive role of all 20 semaphorin family members under the 7 semaphorin classes found in vertebrates and invertebrates as well as the ongoing and emerging therapeutic approaches to combat semaphorin-mediated cancers. Except sema6C, 19 of the 20 non-viral semaphorin family members have been discovered to be associated with cancer in one way or another. Eleven semaphorin family members have been discovered to be tumor proliferative and 8 to be tumor suppressive. Six therapeutic avenues and their safety profiles have been discussed which are currently at use or at the various stages of development. Finally, perspectives on which approach is the best for treating cancers associated with semaphorins have been given.

June 2020
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