Recent developments in the field of deltamethrin (DTM) exposure have led to a renewed interest in alternative antioxidant therapy against toxicity mechanism of DTM. The aim of present study was to evaluate the neuroprotective role of syringic acid (SA) after chronic DTM toxicity on rat hippocampus by biochemical, histopathological, immunohistochemical analysis and learning & memory tests. In this study sixty four adult male Wistar rats were divided into 4 groups consisting of control (I) , deltamethrin (II), deltamethrin + syringic acid (III), syringic acid (IV). [treated with 25 mg/kg doses of syringic acid after deltamethrin exposure with 1.28-1.35 mg / kg doses by oral gavage daily for 2 months]. Spatial and working memory were evaluated by open field and radial arm maze tests.Total antioxidant capacity, reactive oxygen and nitrogen species, glutamate/glutamine expressions and dopamine levels of hippocampus were also determined.
Syringic acid (SA) improved spatial & working memory and locomotor activity against DTM. SA and SA+DTM led to increase total antioxidant capacity, while significantly reduced the oxidative stress and apoptosis (CA1/CA3 subfields) of the hippocampus. It had no significant effects on the glutamate/glutamic acid expression of the hippocampus but enhanced the dopamine levels (p<0,05).A positive correlation was found between dopamine and learning
The study has shown that SA therapy could increase short and long term memory while decreasing oxidative stress and apoptosis in hippocampus after chronic DTM application. An additional important finding to emerge in this study is SA may lead to improve learning and memory with stimulation of dopamine expression.Dr. erenogut, PhD
JOURNAL OF ANATOMY
APR 2020 Volume: 236 Pages: 201-201 Supplement: 1