Significance of minimal residual disease detection by flow cytometry in Paediatric B cell ALL treatment in tertiary care centre in Eastern India

Overview

This is a research work which we ran for 5 years on paediatric B cell ALL patients to see the treatment prognosis by minimal residual disease through Flowcytometry at 15th, 29th day of treatment and post consolidations

Summary

This gives a unique result and a clear picture in the treatment prognosis

Author Comments

dattatreya mukherjee
dattatreya mukherjee
JINAN UNIVERSITY
MEDICAL STUDENT AND RESEARCHER
ONCOLOGY AND HUMAN ANATOMY
GUANGZHOU, GUANGDONG | China
MRD is an important tool to see tumour prognosis dattatreya mukherjee

Resources

Research Gate Paper URL
https://www.researchgate.net/publication/340498765_Significance_of_minimal_residual_disease_detection_by_flow_cytometry_in_Paediatric_B_cell_ALL_treatment_in_tertiary_care_centre_in_Eastern_India

Significance of minimal residual disease detection by flow cytometry in Paediatric B cell ALL treatment in tertiary care centre in Eastern India

IOSR-JDMS

IOSR-JDMS 2020 MAY 19,4(2)11-15

Background: The good prognosis of paediatric B cell acute lymphoblastic leukaemia (pALL) is considered as a great progress of medical science in the field of oncology and haematology. Minimal Residual disease (MRD) refers to the presence of disease in cases deemed to be in complete remission by conventional pathologic analysis. Prognostic importance of MRD in paediatric ALL is well accepted. This is the study where 8 colour flow cytometry (FCM) is used to detect MRD to asses treatment, diagnosis and prognosis of Bcell ALL. Method: Our Study has used 8 the marker. Result: The study includes 52 patients. In the 52 patients 59.6% patients are alive with a p value of 0.031. MRD was checked at 15 th , 29 th day and post consolidation of the treatment where in day 15 (p=0.023), 53.4% positive and 46.5% negative. In day 29 (p=0.031), 22.5% positive and 77.5% negative, in post consolidation positive in 20% and Negative is 80%. MRD value below 0.01 is considered as negative. The overall survival is of 32.88±8.59 months with 6 to 36 months duration. Conclusion: It is a study of 52 patients of paediatric B cell ALL with a detection of MRD by FCM. According to this study day 29 and post consolidation results of MRD show a significant change with that of day 15. This significant early MRD negativity has any role in relapse and prognosis will be look into future study.
April 2020
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