Correlation of Minimal Residual Disease Detection in Paediatric B Cell All Patient with Their Overall Survival and Prognosis- Experience in Tertiary Care Centre in Eastern India

Overview

we have used 8 colour FCM panel which is rare and this gives a good prognostic report and the success of the treatment

Summary

MRD shows how much the treatment is successful so yes its important to see the treatment prognosis part

Author Comments

dattatreya mukherjee
dattatreya mukherjee
JINAN UNIVERSITY
MEDICAL STUDENT AND RESEARCHER
ONCOLOGY AND HUMAN ANATOMY
GUANGZHOU, GUANGDONG | China
This is important research which helps us to understand the treatment prognosis in B cell Pediatric ALL patients. We have seen the significance of testing at day 15, 29 and post consolidations. We have used 8 colour Flowcytometry. dattatreya mukherjee

Resources

Research Gate Paper URL
https://www.researchgate.net/publication/341120148_Corelation_of_Minimal_Residual_Disease_Detection_in_Paediatric_B_Cell_All_Patient_with_Their_Overal_Survival_and_Prognosos-_Experience_in_Tertiary_Care_Centre_in_Eastern_India

Correlation of Minimal Residual Disease Detection in Paediatric B Cell All Patient with Their Overall Survival and Prognosis- Experience in Tertiary Care Centre in Eastern India

IOSR-JDMS

IOSR-JDMS 2020 MAY 19,5(1)1-8

Objectives and Background:To describe clinical outcomes and prognosis i.e overall survival and relapse in the patients with paediatric B cell ALL (pBALL)with respect to minimal residual disease detection on day 15, day 29 and post consolidations in a tertiary care centre in eastern India. Minimal Residual disease (MRD) refers to the presence of disease in cases deemed to be in complete remission by conventional pathologic analysis. Prognostic importance of MRD in paediatric ALL is well accepted all over the world. This is the study where 8 colour flow cytometry (FCM) is used to detect MRD to assestreatment, diagnosis and prognosis of BcellALL. Method:Our Study had been running on 52 paediatric patients with the age group of 1 to 12 years with the MRD analysis on day 15, day 29 and post consolidations and a follow-up of 3 years where we have used 8 colour FCM to detect the MRD analysis. FCM contains CD The patient has gone through a 3 years follow-up and number of patient relapse is determined..Result: The study includes 52 patients. In the 52 patients 59.6% patients are alive with a p value of 31. MRD was checked in every 15 th and the 29 th dayand post consolidation of the treatment where in day 15(p=23), 53.4% positive and 46.5% negative. In day 29(p=31), 22.5 positive and 77.5 negative, in post consolidation positive in 20% and Negative is 80%. MRD value below 0.01 is taken as negative and above is taken as positive. The overall survival(OS) is of 32.88+_ 8.59 with a 6 to 36 months duration. In relapse, no haemorrhagic relapse is found and 2 CNS relapse is found. Conclusion: It is a study of 52 patients of paediatric B cell ALL with a detection of MRD by FCM.MRD negative patient have a good prognosis and comparatively lower rate of relapse than the one with positive MRD. Effort should be made to adhere to recommendation of MRD testing in clinical guidelines.ARTICLE AVAILABLE AT IOSR-JDMS, RESEARCH GATE, ACADEMIA EDU AND GOOGLE
May 2020
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