The aim of this study was to analyze the cytotoxicity of various volumes of 5.25% of sodium hypochlorite, 2% of chlorhexidine gluconate and a mixture of a tetracycline isomer, an acid and a detergent (MTAD) by checking for hemolysis of human red blood corpuscles
This study suggests that the three irrigating solutions do cause detrimental effects on the diluted red blood corpuscles. A great deal of care should, therefore, be exercised when using 5.25% sodium hypochlorite during endodontic irrigation.
The clinical situation, concentration used, exposure time to the agent and the exposure surface area are important factors that affect the cytotoxicity of the irrigating solution. Therefore taking into account the findings of this study chlorhexidine has proven to have the least cytotoxic potential when compared to MTAD and sodium hypochlorite.Dr Vijay Reddy Venumuddala, MDS
Saudi Endodontic Journal
Saudi Endod J 2014;4:1-6