Pathophysiology in laryngeal granulomatous disease

Overview

A 35 year old male presented to our Pneumology Department with a one month history of persistent fever, moderate weight loss (7 kilograms in a week), night sweats, dysphagia, cough and a history of tobacco and alcohol use. Had notable hoarseness of voice and no history of recent tuberculosis contact. No cervical lymphadenopathy.

Summary

Laboratory tests within normal range. By laryngoscopic biopsy, histopathological examination showed necrotising granulomatous inflammation without marks of malignancy. Ziehl Neelsen staining of the tissue and sputum sample revealed both acid fast bacilli and grew mycobacterium tuberculosis on culture.

Author Comments

Dr. Petru-Emil Muntean, MD, Masters Degree
Dr. Petru-Emil Muntean, MD, Masters Degree
Spitalul Judetean de Urgenta Arges, Dispensarul de Pneumoftiziologie Pitesti
Medic specialist pneumolog
Competence in Bronchology and Spirometry
Pitesti, Arges | Romania
Based on national protocol1, he started right away a 4 drug antituberculous therapy and had within a week a good clinical improvement.Dr. Petru-Emil Muntean, MD, Masters Degree

Resources

Pneumon Journal
http://pneumon.org/http-www-pneumon-org-assets-files-pneumon-2019-3-pdf/newsid789/753/showfulltext789/1

Pathophysiology in laryngeal granulomatous disease

Pneumon

http://pneumon.org/http-www-pneumon-org-assets-files-pneumon-2019-3-pdf/newsid789/753/showfulltext789/1

A 35 year old male presented to our Pneumology Department with a one month history of persistent fever, moderate weight loss (7 kilograms in a week), night sweats, dysphagia, cough and a history of tobacco and alcohol use. Had notable hoarseness of voice and no history of recent tuberculosis contact. No cervical lymphadenopathy. Laboratory tests within normal range. By laryngoscopic biopsy, histopathological examination showed necrotising granulomatous inflammation without marks of malignancy. Ziehl Neelsen staining of the tissue and sputum sample revealed both acid fast bacilli and grew mycobacterium tuberculosis on culture. Based on national protocol1, he started right away a 4 drug antituberculous therapy and had within a week a good clinical improvement.
December 2019
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