Cutting Edge: memory regulatory t cells require IL-7 and not IL-2 for their maintenance in peripheral tissues.

J Immunol 2013 May 29;190(9):4483-7. Epub 2013 Mar 29.

Department of Dermatology, University of California San Francisco, San Francisco, CA 94143, USA.

Thymic Foxp3-expressing regulatory T cells are activated by peripheral self-antigen to increase their suppressive function, and a fraction of these cells survive as memory regulatory T cells (mTregs). mTregs persist in nonlymphoid tissue after cessation of Ag expression and have enhanced capacity to suppress tissue-specific autoimmunity. In this study, we show that murine mTregs express specific effector memory T cell markers and localize preferentially to hair follicles in skin. Memory Tregs express high levels of both IL-2Rα and IL-7Rα. Using a genetic-deletion approach, we show that IL-2 is required to generate mTregs from naive CD4(+) T cell precursors in vivo. However, IL-2 is not required to maintain these cells in the skin and skin-draining lymph nodes. Conversely, IL-7 is essential for maintaining mTregs in skin in the steady state. These results elucidate the fundamental biology of mTregs and show that IL-7 plays an important role in their survival in skin.

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Source
http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1300212
Publisher Site
http://dx.doi.org/10.4049/jimmunol.1300212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660612PMC
May 2013
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