Thiamin deficiency in people with obesity.

Adv Nutr 2015 Mar 13;6(2):147-53. Epub 2015 Mar 13.

Department of Medicine, Veterans Affairs Medical Center, Washington, DC; Department of Medicine, George Washington University, Washington, DC;

Although obesity has been viewed traditionally as a disease of excess nutrition, evidence suggests that it may also be a disease of malnutrition. Specifically, thiamin deficiency was found in 15.5-29% of obese patients seeking bariatric surgery. It can present with vague signs and symptoms and is often overlooked in patients without alcohol use disorders. This review explores the relatively new discovery of high rates of thiamin deficiency in certain populations of people with obesity, including the effects of thiamin deficiency and potential underlying mechanisms of deficiency in people with obesity. The 2 observational studies that examined the prevalence in preoperative bariatric surgery patients and gaps in our current knowledge (including the prevalence of thiamin deficiency in the general obese population and whether the current RDA for thiamin meets the metabolic needs of overweight or obese adults) are reviewed. Suggestions for future areas of research are included.

Download full-text PDF

Source
http://dx.doi.org/10.3945/an.114.007526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352173PMC
March 2015
13 Reads

Publication Analysis

Top Keywords

thiamin deficiency
20
people obesity
12
deficiency people
8
bariatric surgery
8
thiamin
6
deficiency
5
rates thiamin
4
high rates
4
deficiency populations
4
obesity including
4
including effects
4
current rda
4
rda thiamin
4
populations people
4
discovery high
4
meets metabolic
4
alcohol disorders
4
knowledge including
4
disorders review
4
review explores
4

References

(Supplied by CrossRef)
Diet and health: implications for reducing chronic disease risk
National Research Council Committee on Diet and Health. et al.
1989
Associations between body mass index and the prevalence of low micronutrient levels among US adults
Kimmons et al.
MedGenMed 2006
Vitamin B1 status assessed by direct measurement of thiamin pyrophosphate in erythrocytes or whole blood by HPLC: comparison with erythrocyte transketolase activation assay
Talwar et al.
Clin Chem 2000

Similar Publications