Application of nanotechnology in cancer therapy and imaging.

CA Cancer J Clin 2008 Mar-Apr;58(2):97-110. Epub 2008 Jan 28.

Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.

Recent developments in nanotechnology have provided researchers with new tools for cancer imaging and treatment. This technology has enabled the development of nanoscale devices that can be conjugated with several functional molecules simultaneously, including tumor-specific ligands, antibodies, anticancer drugs, and imaging probes. Since these nanodevices are 100 to 1,000-fold smaller than cancer cells, they can be easily transferred through leaky blood vessels and interact with targeted tumor-specific proteins both on the surface of and inside cancer cells. Therefore, their application as cancer cell-specific delivery vehicles will be a significant addition to the currently available armory for cancer therapeutics and imaging.

Download full-text PDF

Source
http://dx.doi.org/10.3322/CA.2007.0003DOI Listing
August 2008
3 Reads

Publication Analysis

Top Keywords

cancer cells
8
cancer
6
cells application
4
ligands antibodies
4
antibodies anticancer
4
inside cancer
4
drugs imaging
4
anticancer drugs
4
application cancer
4
tumor-specific ligands
4
vessels interact
4
cell-specific delivery
4
molecules simultaneously
4
cancer cell-specific
4
including tumor-specific
4
simultaneously including
4
imaging probes
4
probes nanodevices
4
targeted tumor-specific
4
easily transferred
4

Altmetric Statistics

Similar Publications