Fluorescent nanothermometers provide controlled plasmonic-mediated intracellular hyperthermia.

Nanomedicine (Lond) 2013 Mar 2;8(3):379-88. Epub 2012 Dec 2.

Fluorescence Imaging Group, Departamento de Física de Materiales, Facultad de Ciencias, Instituto Nicolás Cabrera, Universidad Autónoma de Madrid, 28049 Madrid, Spain.

Aim: This article demonstrates how controlled hyperthermia at the cellular level can be achieved.

Materials & Methods: The method is based on the simultaneous intracellular incorporation of fluorescence nanothermometers (CdSe quantum dots) and metallic nanoheaters (gold nanorods).

Results: Real-time spectral analysis of the quantum dot emission provides a detailed feedback about the intracellular thermal loading caused by gold nanorods excited at the plasmon frequency. Based on this approach, thermal dosimetry is assessed in such a way that the infrared laser (heating) power required to achieve catastrophic intracellular temperature increments in cancer cells is identified.

Conclusions: This pure optical method emerges as a new and promising guide for the development of infrared hyperthermia therapies with minimal invasiveness.

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http://dx.doi.org/10.2217/nnm.12.122DOI Listing
March 2013
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