Isoform-specific ras functions in development and cancer.

Future Oncol 2009 Feb;5(1):105-16

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.

The three closely related mammalian ras genes, Hras, Nras and Kras, have each been implicated in human tumorigenesis by virtue of mutational activation. However, while these genes encode proteins with very similar biochemical properties, activating ras alleles corresponding to the various isoforms have been linked to particular malignancies. Accumulating evidence suggests that these proteins exert distinct activities in a tissue-specific context, apparently reflecting developmental lineage-specific roles for the various ras isoforms. Some of these distinct functions appear to reflect differences in their C-termini, which determine distinct subcellular localization, thereby suggesting a role for compartmentalized signaling. In this review, we discuss the biological functions of the ras isoforms in the context of tissue-specific function as it relates to ras function in development and human cancer.

Download full-text PDF

Source
http://dx.doi.org/10.2217/14796694.5.1.105DOI Listing
February 2009
62 Reads

Publication Analysis

Top Keywords

ras isoforms
8
ras
5
developmental lineage-specific
4
reflecting developmental
4
lineage-specific roles
4
context reflecting
4
roles ras
4
functions appear
4
distinct functions
4
isoforms distinct
4
tissue-specific context
4
appear reflect
4
activities tissue-specific
4
linked malignancies
4
isoforms linked
4
corresponding isoforms
4
alleles corresponding
4
malignancies accumulating
4
accumulating evidence
4
distinct activities
4

References

(Supplied by CrossRef)

Rajalingam et al.
Biochim. Biophys. Acta 2007

Adjei et al.
J. Natl Cancer Inst. 2001

Drivas et al.
Biochem. Biophys. Res. Commun. 1991

Jekely et al.
Bioessays 2003

Jiang et al.
Physiol. Genomics 2006

Colicelli et al.
Sci. STKE 2004

Crespo et al.
Cell. Mol. Life Sci. 2000

Friday et al.
Biochim. Biophys. Acta 2005

Similar Publications