Glioma grading by microvascular permeability parameters derived from dynamic contrast-enhanced MRI and intratumoral susceptibility signal on susceptibility weighted imaging.

Cancer Imaging 2015 Mar 21;15. Epub 2015 Mar 21.

Department of Radiology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.

Background: Dynamic contrast-enhanced MRI (DCE-MRI) estimates vascular permeability of brain tumors, and susceptibility-weighted imaging (SWI) may demonstrate tumor vascularity by intratumoral susceptibility signals (ITSS). This study assessed volume transfer constant (Ktrans) accuracy, the volume of extravascular extracellular space (EES) per unit volume of tissue (Ve) derived from DCE-MRI, and the degree of ITSS in glioma grading.

Methods: Thirty-two patients with different glioma grades were enrolled in this retrospective study. Patients underwent DCE-MRI and non-contrast enhanced SWI by three-tesla scanning. Ktrans values, Ve, and the degree of ITSS in glioma were compared. Receiver operating characteristic (ROC) curve analysis determined diagnostic performances of Ktrans and Ve in glioma grading, and Spearman's correlation analysis determined the associations between Ktrans, Ve, ITSS, and tumor grade.

Results: Ktrans and Ve values were significantly different between low grade gliomas (LGGs) and both high grade gliomas (HGGs) and grade II, III and IV gliomas (P<0.01). The degree of ITSS of LGGs was lower than HGGs (P<0.01), and the ITSS of grade II gliomas was lower than grade III or IV gliomas. Ktrans and Ve were correlated with glioma grade (P<0.01), while ITSS was moderately correlated (P<0.01). Ktrans values were moderately correlated with ITSS in the same segments (P<0.01).

Conclusion: Ktrans and Ve values, and ITSS helped distinguish the differences between LGGs and HGGs and between grade II, III and IV gliomas. There was a moderate correlation between Ktrans and ITSS in the same tumor segments.

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40644-015-0039-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389664PMC
March 2015
32 Reads

Publication Analysis

Top Keywords

grade gliomas
8
contrast-enhanced mri
8
ktrans values
8
intratumoral susceptibility
8
analysis determined
8
itss glioma
8
dynamic contrast-enhanced
8
degree itss
8
glioma grading
8
ktrans
5
glioma
5
extracellular space
4
volume extravascular
4
roc curve
4
extravascular extracellular
4
characteristic roc
4
unit volume
4
ees unit
4
operating characteristic
4
space ees
4

References

(Supplied by CrossRef)

MC Tate et al.
Neurotherapeutics 2009

P Mahzouni et al.
Indian J Pathol Microbiol 2010

M Onishi et al.
Brain Tumor Pathol 2011

A Jackson et al.
Br J Radiol 2003

S Lacerda et al.
Neuroimaging Clin North Am 2009

Z Jia et al.
J Clin Neurosci 2013

R Jain et al.
NMR Biomed 2013

Z Jia et al.
J Clin Neurosci 2012

HS Kim et al.
AJNR Am J Neuroradiol 2009

MJ Park et al.
AJNR Am J Neuroradiol 2009

DN Louis et al.
Acta Neuropathol 2007

Similar Publications