Understanding the colon cancer stem cells and perspectives on treatment.

Cancer Cell Int 2015 28;15(1). Epub 2015 Jan 28.

Laboratorio de Terapia Celular, Departamento de Bioquímica y Medicina Molecular, Facultad de Medicina, Universidad Autónoma de Nuevo León, León, Mexico.

An area of research that has been recently gaining attention is the relationship between cancer stem cell (CSC) biology and chemo-resistance in colon cancer patients. It is well recognized that tumor initiation, growth, invasion and metastasis are promoted by CSCs. An important reason for the widespread interest in the CSC model is that it can comprehensibly explain essential and poorly understood clinical events, such as therapy resistance, minimal residual disease, and tumor recurrence. This review discusses the recent advances in colon cancer stem cell research, the genes responsible for CSC chemoresistance, and new therapies against CSCs.

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http://dx.doi.org/10.1186/s12935-015-0163-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4328053PMC
February 2015
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