Proteinases in the joint: clinical relevance of proteinases in joint destruction.

Arthritis Res Ther 2007 ;9(5):221

Center of Experimental Rheumatology, University Hospital Zürich, Gloriastrasse, CH-8091 Zurich, Switzerland.

Proteinases are involved in essential steps in cartilage and bone homeostasis. Consequently, efforts have been made to establish their potential role in the pathology of rheumatic conditions such as rheumatoid arthritis, osteoarthritis and spondyloarthritis. Matrix metalloproteinases (MMPs) are sensitive markers of disease severity and response to treatment, and therefore they have potential in the assessment of rheumatic diseases. Despite disappointing early results with synthetic inhibitors of MMPs, there is still much scope for developing effective and safe MMPs inhibitors, and consequently to deliver new options to inhibit joint destruction.

Download full-text PDF

Source
http://dx.doi.org/10.1186/ar2304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212555PMC
April 2008
7 Reads

Publication Analysis

Top Keywords

joint destruction
8
proteinases joint
8
developing effective
4
rheumatic conditions
4
conditions rheumatoid
4
scope developing
4
pathology rheumatic
4
disease severity
4
diseases despite
4
effective safe
4
establish potential
4
potential role
4
severity response
4
role pathology
4
rheumatoid arthritis
4
arthritis osteoarthritis
4
inhibitors mmps
4
metalloproteinases mmps
4
mmps sensitive
4
synthetic inhibitors
4

Similar Publications