Frontostriatal functional connectivity in major depressive disorder.

Biol Mood Anxiety Disord 2011 Dec 8;1(1):11. Epub 2011 Dec 8.

Department of Psychology, Stanford University, 450 Serra Mall, Stanford, CA 94305-2004, USA.

Background: Abnormalities of the striatum and frontal cortex have been reported consistently in studies of neural structure and function in major depressive disorder (MDD). Despite speculation that compromised connectivity between these regions may underlie symptoms of MDD, little work has investigated the integrity of frontostriatal circuits in this disorder.

Methods: Functional magnetic resonance images were acquired from 21 currently depressed and 19 never-disordered women during wakeful rest. Using four predefined striatal regions-of-interest, seed-to-whole brain correlations were computed and compared between groups.

Results: Compared to controls, depressed participants exhibited attenuated functional connectivity between the ventral striatum and both ventromedial prefrontal cortex and subgenual anterior cingulate cortex. Depressed participants also exhibited stronger connectivity between the dorsal caudate and dorsal prefrontal cortex, which was positively correlated with severity of the disorder.

Conclusions: Depressed individuals are characterized by aberrant connectivity in frontostriatal circuits that are posited to support affective and cognitive processing. Further research is required to examine more explicitly the link between patterns of disrupted connectivity and specific symptoms of depression, and the extent to which these patterns precede the onset of depression and normalize with recovery from depressive illness.

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http://dx.doi.org/10.1186/2045-5380-1-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384258PMC
December 2011

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References

(Supplied by CrossRef)

RC Kessler et al.
2009

IH Gotlib et al.
Annu Rev Clin Psychol 2010

P Videbach et al.
Acta Psychiatr Scand 2000

RT Dunn et al.
Biol Psychiatry 2002

JW Mink et al.
Prog Neurobiol 1996

S Grillner et al.
Trends Neurosci 2005

MJ Frank et al.
Cogn Affect Behav Neurosci 2001

GE Alexander et al.
Ann Rev Neurosci 1986

SN Haber et al.
J Neurosci 2000

WR Marchand et al.
Brain Struct Funct 2010

MA Rogers et al.
Brain Res Bull 1998

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