Platelet-derived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty.

J Clin Invest 1992 Feb;89(2):507-11

Department of Surgery, University of Washington School of Medicine, Seattle 98195.

Platelet-derived growth factor (PDGF) is a mitogen and chemoattractant for vascular smooth muscle cells (SMC) in vitro, but its activities in vivo remain largely undefined. We infused recombinant PDGF-BB (0.01-0.30 mg/kg per d i.v.) into rats subjected to carotid injury. PDGF-BB produced a small increase (two- to threefold) in medial SMC proliferation. More importantly, PDGF-BB greatly increased (20-fold) the intimal thickening and the migration of SMC from the media to the intima during the first 7 d after injury. These data provide support for the hypothesis that PDGF, and perhaps other platelet factors, might play an important role in the movement of mesenchymal cells into zones of injury undergoing repair.

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Source
http://www.jci.org/articles/view/115613
Publisher Site
http://dx.doi.org/10.1172/JCI115613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC442880PMC
February 1992
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