Morphology of the sinus node in human and mouse hearts with isomerism of the atrial appendages.

Br Heart J 1995 Oct;74(4):437-42

Department of Paediatrics, National Heart and Lung Institute, London.

Background: The location of the sinus node is known to be at best abnormal, or at worst unknown, in patients with isomerism of the morphologically left atrial appendage. In contrast, the sinus node is known to be an excellent histological marker of the morphologically right appendage, being duplicated in those with right isomerism. The aim of the study was to investigate this condition further in fetal human and mouse hearts.

Methods: Serial histological sections of the area anticipated to contain the sinus node were studied in hearts with isomerism of the atrial appendages taken from 14 human fetuses and 13 iv/iv mice, using 12 mouse hearts with normally arranged or mirror imaged atrial chambers for controls.

Results: All hearts with isomerism of the right appendages (two human and four mouse) had bilateral sinus nodes. The cases with isomerism of the left appendages (12 human and nine mouse) showed absence of a recognisable sinus node except in four cases (19%) in which a small remnant of the node was found. In three of these cases, it was related postero-inferiorly to the superior cavoatrial junction.

Conclusions: The concept of isomerism of the atrial appendages is endorsed by findings on the morphology of the sinus node, this being the most reliable histological criterion for existence of a morphologically right atrium. A small proportion of hearts with left isomerism had a structure resembling the sinus node, but it was hypoplastic and displaced postero-inferiorly, distant from its expected position had the hearts possessed an incompletely formed morphologically right appendage.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC484053PMC
http://dx.doi.org/10.1136/hrt.74.4.437DOI Listing
October 1995
2 Reads

Publication Analysis

Top Keywords

sinus node
28
human mouse
16
hearts isomerism
12
isomerism atrial
12
appendages human
12
atrial appendages
12
isomerism
8
node
8
morphologically appendage
8
mouse hearts
8
morphology sinus
8
sinus
7
hearts
6
mouse
5
appendages
5
atrial
5
human
5
recognisable sinus
4
node cases
4
isomerism left
4

References

(Supplied by CrossRef)
Isomerism of the cardiac atria in the asplenia syndrome
LHS, Van Mierop; FW, Wiglesworth et al.
Lab Invest
Isomerism of the atrial appendages-goodbye to asplenia
Becker, A.E.; Anderson, R.H. et al.
1990
The location and vascular supply of the sinus node in the human heart
Anderson, K.R.; Ho, S.Y.; Anderson, R.H. et al.
Br Heartj 1979
Sinus node function: evaluation in patients with and without sinus node disease
Mandel, W.J.; Lak, M.M.; Obayashi, K. et al.
Arch Intern Med 1975
Isomerism of the atrial appendages in the fetus
Ho, S.Y.; Cook, A.; Anderson, R.H.; Allan, L.D.; Fagg, N. et al.
Pediatr Pathol 1991
Abnormal laterality and congenital cardiac anomalies: relationships of visceral and cardiac morphologies in the ivliv mouse
Seo, J.W.; Brown, N.A.; Ho, S.Y.; Anderson, R.H. et al.
Circulation 1992
Histologic study of the cardiac conducting system as a routine procedure
Smith, A.; Ho, S.Y.; Anderson, R.H. et al.
Med Lab Sci 1977
Anatomy of the human sinus node
James, T.N. et al.
Anat Rec
Reconstruction of the human sinoatrial node
Truex, R.C.; Smythe, M.Q.; Taylor, M.J. et al.
AnatRec 1967

Similar Publications