Renalase, a new secretory enzyme responsible for selective degradation of catecholamines: achievements and unsolved problems.

Biochemistry (Mosc) 2010 Aug;75(8):951-8

Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, 119121, Russia.

Renalase is a recently discovered secretory enzyme responsible for selective degradation of blood catecholamines. The review summarizes literature data on expression of this enzyme and on its structure and functions. Special attention is paid to unsolved and questionable problems including: 1) prediction of the presence of FAD in the protein structure based on amino acid sequence similarity of renalase with known FAD-dependent enzymes; 2) identity of plasma and urinary renalase; 3) mechanism underlying conversion of inactive renalase into the active form.

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http://dx.doi.org/10.1134/s0006297910080018DOI Listing
August 2010

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References

(Supplied by CrossRef)

J. Xu et al.
J. Clin. Invest. 2005

F. C. Luft et al.
Cell Metab. 2005

F. Boomsma et al.
J. Neural. Transm. 2007

Q. Zhao et al.
J. Mol. Med. 2007

S. S. Ghosh et al.
Pediatr. Nephrol. 2009

G. Eisenhofer et al.
Pharmacol. Rev. 2004

J. O’sullivan et al.
Neurotoxicology 2004

J. P. Klinman et al.
Biochim. Biophys. Acta 2003

F. Boomsma et al.
Biochim. Biophys. Acta 2003

C. Gokturk et al.
Am. J. Hyperten. 2007

S. Y. Lin et al.
Food Chem. Toxicol. 2008

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