Macroevolution of complex retroviruses.

Science 2009 Sep;325(5947):1512

Zoology Department, University of Oxford, Oxford OX1 3PS, UK.

Retroviruses can leave a "fossil record" in their hosts' genomes in the form of endogenous retroviruses. Foamy viruses, complex retroviruses that infect mammals, have been notably absent from this record. We have found an endogenous foamy virus within the genomes of sloths and show that foamy viruses were infecting mammals more than 100 million years ago and codiverged with their hosts across an entire geological era. Our analysis highlights the role of evolutionary constraint in maintaining viral genome structure and indicates that accessory genes and mammalian mechanisms of innate immunity are the products of macroevolutionary conflict played out over a geological time scale.

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http://dx.doi.org/10.1126/science.1174149DOI Listing
September 2009
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References

(Supplied by CrossRef)

Weiss et al.
2006

Wolf et al.
Annual review of genetics 2008

Delsuc et al.
BMC evolutionary biology [electronic resource] 2004

Bininda-Emonds et al.
Nature; Physical Science (London) 2007

Huchon et al.
Proceedings of the Royal Society B: Biological Sciences 2000

Switzer et al.
Nature; Physical Science (London) 2005

Holmes et al.
Journal of Virology 2003

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