A common variant on chromosome 9p21 affects the risk of myocardial infarction.

Science 2007 Jun 3;316(5830):1491-3. Epub 2007 May 3.

deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland.

The global endemic of cardiovascular diseases calls for improved risk assessment and treatment. Here, we describe an association between myocardial infarction (MI) and a common sequence variant on chromosome 9p21. This study included a total of 4587 cases and 12,767 controls. The identified variant, adjacent to the tumor suppressor genes CDKN2A and CDKN2B, was associated with the disease with high significance. Approximately 21% of individuals in the population are homozygous for this variant, and their estimated risk of suffering myocardial infarction is 1.64 times as great as that of noncarriers. The corresponding risk is 2.02 times as great for early-onset cases. The population attributable risk is 21% for MI in general and 31% for early-onset cases.

Download full-text PDF

Source
http://link.springer.com/content/pdf/10.1007/s11033-008-9259
Web Search
https://uni.hi.is/apalsson/files/2011/10/MI_S07.pdf
Web Search
http://www.sciencemag.org/cgi/doi/10.1126/science.1142842
Publisher Site
http://dx.doi.org/10.1126/science.1142842DOI Listing
June 2007
29 Reads
508 Citations
31.480 Impact Factor

Publication Analysis

Top Keywords

myocardial infarction
12
early-onset cases
8
variant chromosome
8
chromosome 9p21
8
times great
8
risk
5
great noncarriers
4
noncarriers corresponding
4
controls identified
4
identified variant
4
variant adjacent
4
adjacent tumor
4
12767 controls
4
4587 cases
4
included total
4
estimated risk
4
study included
4
risk 202
4
total 4587
4
cases 12767
4

References

(Supplied by CrossRef)

Circulation Meeting Abstracts 2006

Devlin et al.
Biometrics 1999

Mantel et al.
JNCI Journal of the National Cancer Institute 1959

Zdravkovic et al.
Journal of internal medicine 2002

Kim et al.
Cell 2006

Lusis et al.
Nature; Physical Science (London) 2000

Minamino et al.
Circulation Research 2007

Zintzaras et al.
Journal of human genetics 2006

Wang et al.
American journal of human genetics 2004

American journal of human genetics 2005

Similar Publications