A common allele on chromosome 9 associated with coronary heart disease.

Science 2007 Jun 3;316(5830):1488-91. Epub 2007 May 3.

Division of Cardiology, University of Ottawa Heart Institute, Ottawa K1Y4W7, Canada.

Coronary heart disease (CHD) is a major cause of death in Western countries. We used genome-wide association scanning to identify a 58-kilobase interval on chromosome 9p21 that was consistently associated with CHD in six independent samples (more than 23,000 participants) from four Caucasian populations. This interval, which is located near the CDKN2A and CDKN2B genes, contains no annotated genes and is not associated with established CHD risk factors such as plasma lipoproteins, hypertension, or diabetes. Homozygotes for the risk allele make up 20 to 25% of Caucasians and have a approximately 30 to 40% increased risk of CHD.

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1142447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711874PMC
June 2007
120 Reads

Publication Analysis

Top Keywords

coronary heart
8
heart disease
8
established chd
4
chd independent
4
independent samples
4
samples 23000
4
diabetes homozygotes
4
homozygotes risk
4
associated chd
4
risk factors
4
interval chromosome
4
58-kilobase interval
4
chromosome 9p21
4
risk allele
4
consistently associated
4
9p21 consistently
4
associated established
4
hypertension diabetes
4
located cdkn2a
4
genes associated
4

References

(Supplied by CrossRef)

Murray et al.
Lancet 1997

Mathers et al.
2006

Human Molecular Genetics 2007

THE ARIC INVESTIGATORS et al.
American Journal of Epidemiology 1989

European Heart Journal 2001

Victor et al.
The American journal of cardiology 2004

Agatston et al.
Journal of the American College of Cardiology 1990

Foster et al.
Cancer Research 2007

PNAS 2006

Armstrong et al.
New England Journal of Medicine 2006

Romeo et al.
Nature genetics 2007

Similar Publications