The danger model: a renewed sense of self.

Authors:
Polly Matzinger

Science 2002 Apr;296(5566):301-5

Ghost Lab, Laboratory for Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

For over 50 years immunologists have based their thoughts, experiments, and clinical treatments on the idea that the immune system functions by making a distinction between self and nonself. Although this paradigm has often served us well, years of detailed examination have revealed a number of inherent problems. This Viewpoint outlines a model of immunity based on the idea that the immune system is more concerned with entities that do damage than with those that are foreign.

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Source
http://www.sciencemag.org/cgi/doi/10.1126/science.1071059
Publisher Site
http://dx.doi.org/10.1126/science.1071059DOI Listing
April 2002
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