Cutaneous polyarteritis nodosa: a clinical and histopathological study of 20 cases.

Authors:
K R Chen

J Dermatol 1989 Dec;16(6):429-42

Twenty cases diagnosed as cutaneous polyarteritis nodosa (CPN) and confirmed by skin biopsy over the last 17 years were reviewed in our department. Based upon their clinical features, laboratory findings, and long-term observation of the disease course, they were divided into three groups. 1) Group 1 comprised 16 cases which were classified as the mild cutaneous form. The disease was confined to the skin with occasional involvement of peripheral nerves and skeletal muscles of the affected extremity. They generally followed a benign course. 2) Group 2 comprised 2 cases classified as the severe form. Despite severe clinical manifestations and several abnormal laboratory findings, the disease was limited to the skin, muscles, and peripheral nerves without any visceral involvement over follow-up periods of 11 years and 5 years, respectively. 3) Group 3 comprised 2 cases of the progressive form; in these the disease had begun with a cutaneous lesion and progressed to the systemic form after 19 and 18 year periods of recurrent episodes of cutaneous lesions, respectively. One died of gastrointestinal bleeding. In group 3, serum antinuclear antibodies and rheumatoid factor were positive. The autoimmune mechanism seems to play a role in this group. It is clear from the results of this study that not all patients whose vasculitic lesions are apparently limited to the skin remain in a benign course. Long-term follow-up is essential.

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1346-8138.1989.tb01582.xDOI Listing
December 1989

Publication Analysis

Top Keywords

group comprised
12
comprised cases
12
limited skin
8
cases classified
8
laboratory findings
8
benign course
8
form disease
8
polyarteritis nodosa
8
peripheral nerves
8
cutaneous polyarteritis
8
cutaneous
5
group
5
cases
5
muscles peripheral
4
skin muscles
4
disease begun
4
nerves visceral
4
involvement follow-up
4
years years
4
cases progressive
4

References

(Supplied by CrossRef)
Ein Beitrag zur Kenntnis der Periarteritis nodosa
Lindberg et al.
Acta Med Scand 1931
Cutaneous polyarteritis nodosa
Borrie et al.
Br J Dermatol 1972
Cutaneous periarteritis nodosa
Diaz-Perez et al.
Arch Dermatol 1974
Cutaneous periarteritis nodosa: A study of 33 cases
Diaz-Perez et al.
1980
Cutaneous polyaretritis nodosa syndrome
Cupp et al.
1981
Chronic cutaneous polyarteritis nodosa simulating recurrent thrombophlebitis
Zimran et al.
Isr J Med Sci 1985

Similar Publications