Real-world use of elbasvir-grazoprevir in patients with chronic hepatitis C: retrospective analyses from the TRIO network.

Aliment Pharmacol Ther 2018 06 17;47(11):1511-1522. Epub 2018 Apr 17.

Beth Israel Deaconess Medical Center, Boston, MA, USA.

Background: Elbasvir-grazoprevir is indicated for chronic hepatitis C virus (HCV) genotypes 1 and 4.

Aim: To evaluate the utilization and outcomes of chronic HCV patients treated with elbasvir-grazoprevir in the United States.

Methods: We conducted a retrospective cohort study of adults treated with elbasvir-grazoprevir with or without ribavirin for chronic HCV genotypes 1 or 4 infection. Data were collected from healthcare providers and specialty pharmacies through Innervation Platform, a proprietary, cloud-based disease management program from Trio Health. The primary endpoint was per protocol sustained virological response 12 weeks post-treatment (SVR12).

Results: Among 470 patients treated in 2016, 95% had HCV genotype 1 infection, 80% (373/468) were HCV treatment naïve and 70% (327/468) had non-cirrhotic disease. Almost 3 quarters (73%) of patients received care in community practices. The majority (89%) of patients received elbasvir-grazoprevir for 12 weeks. Per protocol SVR12 rates were 99% (396/402) for HCV genotype 1 and 95% (21/22) for HCV genotype 4. Among patients with Stage 4 or 5 chronic kidney diseases, 99% (113/114) achieved SVR12. In univariate analyses, variables significantly associated with per protocol SVR12 for the entire sample were therapy duration (P = 0.001), treatment experience (P = 0.016), and cirrhosis status (P = 0.001). However, among HCV genotype 1 patients, no variables were significant. Intent-to-treat SVR12 rates were 89% (396/447) for HCV genotype 1 and 91% (21/23) for HCV genotype 4.

Conclusion: Elbasvir-grazoprevir is highly effective, and in this 2016 cohort, its use was predominantly in patients with HCV genotype 1 and as a 12-week therapy without ribavirin.

Download full-text PDF

Source
http://dx.doi.org/10.1111/apt.14635DOI Listing
June 2018
22 Reads

Publication Analysis

Top Keywords

hcv genotype
28
hcv
11
treated elbasvir-grazoprevir
8
patients treated
8
chronic hepatitis
8
chronic hcv
8
genotype patients
8
patients received
8
patients
8
hcv genotypes
8
svr12 rates
8
protocol svr12
8
genotype
7
elbasvir-grazoprevir
5
chronic
5
genotype infection
4
experience 0016
4
infection 80%
4
95% hcv
4
373/468 hcv
4

Similar Publications