t(5;9)(q11;q34): a novel familial translocation involving Abelson oncogene and association with hypereosinophilia.

J Pediatr Hematol Oncol 2003 Jan;25(1):82-4

Division of Pediatric Hematology and Oncology, Children's Hospital of Michigan, 39012 Beaubien Boulevard, Detroit, MI 48201, USA.

A 6-year-old girl with hypereosinophilia was found to have a familial constitutional translocation t(5;9)(q11;q34). Flow cytometry and gene rearrangement studies did not show any clonal T-helper cell proliferation. Presence of cryptic Philadelphia translocation was ruled out by reverse transcription polymerase chain reaction. Abelson oncogene translocation on chromosome 5 was confirmed by fluorescent in situ hybridization. This is the first example of a familial translocation involving the abelson oncogene and association with hypereosinophilia. The authors discuss a novel mechanism of hypereosinophilia involving the hybrid product of the abelson oncogene with an unknown partner gene on chromosome 5 (probably granzyme-A).

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http://dx.doi.org/10.1097/00043426-200301000-00017DOI Listing
January 2003
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