The role of beta-catenin in cell adhesion, signal transduction, and cancer.

Curr Opin Oncol 1998 Jan;10(1):81-7

Department of Molecular Biology, Princeton University, NJ 08544, USA.

Beta-catenin is a multifunctional protein that is both an integral component of adherens junctions and a pivotal member of a signal transduction pathway. The cytoplasmic pool of beta-catenin, which participates in signal transduction, is highly regulated. Binding to the adenomatous polyposis coli tumor suppressor protein can stimulate the degradation of beta-catenin, whereas signaling initiated by the extracellular Wnt-1 oncoprotein or selected mutations in beta-catenin itself results in the accumulation of higher levels of beta-catenin in the cytoplasm. A variety of experiments from several model systems have converged to elucidate the mechanisms involved in this regulation as well as the downstream effectors of beta-catenin. These studies have recently been extended to demonstrate that deregulation of this pathway contributes to cancer in humans.

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http://dx.doi.org/10.1097/00001622-199801000-00013DOI Listing
January 1998
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