Clinical impact of urinary CD11b and CD163 on the renal outcomes of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis.

Nephrol Dial Transplant 2020 Jul 8. Epub 2020 Jul 8.

Nagoya University, Nagoya, Japan.

Background: The detection of leukocyte-derived CD11b (α subunit of integrin Mac-1) and CD163 (scavenger receptor) in urine may reflect renal inflammation in antineutrophil cytoplasmic antibody-associated glomerulonephritis (ANCA-GN). The objective of this study was to evaluate the clinical significance of urinary CD11b (U-CD11b) and CD163 (U-CD163) in ANCA-GN.

Methods: U-CD11b and U-CD163 were examined using enzyme-linked immunosorbent assay in ANCA-GN urine samples from our institutional cohort (n = 88) and a nationwide cohort (n = 138), and their association with renal histology was subsequently analyzed. Logistic regression analyses were performed on a nationwide ANCA cohort to determine the associations of the two urinary molecules with renal remission failure at 6 months or with yearly estimated glomerular filtration rate (eGFR) slope over a 24-month observation period.

Results: U-CD11b and U-CD163 were significantly associated with cellular crescent formation and leukocyte accumulation in glomerular crescents. With regard to interstitial inflammation, both levels of U-CD11b and U-CD163 at diagnosis remarkably increased in ANCA-GN compared with the levels observed in nonglomerular kidney disorders including nephrosclerosis, immunoglobulin G4-related disease and tubulointerstitial nephritis; however, the presence of U-CD11b alone was significantly correlated with tubulointerstitial leukocyte infiltrates. Although neither U-CD11b nor U-CD163 at diagnosis was associated with remission failure at 6 months, multivariate analysis demonstrated that the baseline U-CD11b levels were significantly associated with the increase in eGFR following immunosuppressive therapy.

Conclusions: Although both U-CD11b and U-CD163 reflect renal leukocyte accumulation, U-CD11b at diagnosis provides additional clinical value by predicting the recovery rate after the treatment of ANCA-GN.

Download full-text PDF

Source
http://dx.doi.org/10.1093/ndt/gfaa097DOI Listing
July 2020

Publication Analysis

Top Keywords

u-cd11b u-cd163
20
u-cd11b
9
antibody-associated glomerulonephritis
8
cytoplasmic antibody-associated
8
u-cd163 diagnosis
8
failure 6 months
8
reflect renal
8
leukocyte accumulation
8
remission failure
8
urinary cd11b
8
u-cd163
6
renal
5
including nephrosclerosis
4
samples institutional
4
regression analyses
4
institutional cohort
4
logistic regression
4
analyzed logistic
4
nephrosclerosis immunoglobulin
4
disorders including
4

References

(Supplied by CrossRef)
The macrophage scavenger receptor CD163
Fabriek et al.
Immunobiology 2005
Urinary soluble CD163 in active renal vasculitis
O’Reilly et al.
J Am Soc Nephrol 2016

Similar Publications