Hum Mutat 2020 Mar 30. Epub 2020 Mar 30.
USF Genomics & College of Public Health, University of South Florida, Tampa, FL.
microRNAs (miRNAs) are short noncoding RNAs that can repress the expression of protein-coding messenger RNAs (mRNAs) by binding to the 3'UTR of the target. Genetic mutations such as single nucleotide variants (SNVs) in the 3'UTR of the mRNAs can disrupt miRNA regulation. In this study, we presented dbMTS, a database for miRNA target site SNVs and their functional annotations. This database can help studies easily identify putative SNVs that affect miRNA targeting and facilitate the prioritization of their functional importance. dbMTS is freely available for academic use at http://database.liulab.science/dbMTS as a web-service or a downloadable attached database of dbNSFP. This article is protected by copyright. All rights reserved.