dbMTS: a comprehensive database of putative human microRNA target site SNVs and their functional predictions.

Hum Mutat 2020 Mar 30. Epub 2020 Mar 30.

USF Genomics & College of Public Health, University of South Florida, Tampa, FL.

microRNAs (miRNAs) are short noncoding RNAs that can repress the expression of protein-coding messenger RNAs (mRNAs) by binding to the 3'UTR of the target. Genetic mutations such as single nucleotide variants (SNVs) in the 3'UTR of the mRNAs can disrupt miRNA regulation. In this study, we presented dbMTS, a database for miRNA target site SNVs and their functional annotations. This database can help studies easily identify putative SNVs that affect miRNA targeting and facilitate the prioritization of their functional importance. dbMTS is freely available for academic use at http://database.liulab.science/dbMTS as a web-service or a downloadable attached database of dbNSFP. This article is protected by copyright. All rights reserved.

Download full-text PDF

Source
http://dx.doi.org/10.1002/humu.24020DOI Listing
March 2020

Publication Analysis

Top Keywords

target site
8
snvs functional
8
site snvs
8
dbmts database
4
mirna target
4
database mirna
4
annotations database
4
easily identify
4
studies easily
4
help studies
4
database help
4
functional annotations
4
presented dbmts
4
nucleotide variants
4
variants snvs
4
single nucleotide
4
mutations single
4
genetic mutations
4
snvs 3'utr
4
3'utr mrnas
4

Similar Publications