Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells.

J Exp Med 2004 Feb;199(3):303-13

Experimentelle Rheumatologie, Medizinische Klinik, Charité, Humboldt-Universitaet, Schumannstr. 21/22, 10117 Berlin, Germany.

Regulatory T cells (Tregs) fulfill a central role in immune regulation. We reported previously that the integrin alphaEbeta7 discriminates distinct subsets of murine CD4+ regulatory T cells. Use of this marker has now helped to unravel a fundamental dichotomy among regulatory T cells. alphaE-CD25+ cells expressed L-selectin and CCR7, enabling recirculation through lymphoid tissues. In contrast, alphaE -positive subsets (CD25+ and CD25-) displayed an effector/memory phenotype expressing high levels of E/P-selectin-binding ligands, multiple adhesion molecules as well as receptors for inflammatory chemokines, allowing efficient migration into inflamed sites. Accordingly, alphaE -expressing cells were found to be the most potent suppressors of inflammatory processes in disease models such as antigen-induced arthritis.

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http://www.jem.org/lookup/doi/10.1084/jem.20031562
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http://dx.doi.org/10.1084/jem.20031562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211798PMC
February 2004
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