[Impact of interleukin-10 and interleukin-28 gene polymorphisms on the development and course of lupus nephritis].

Ter Arkh 2015 ;87(6):40-44

Department of Internal Medicine, Faculty of Fundamental Medicine, M.V. Lomonosov Moscow State University, Moscow, Russia.

Aim: To assess the relationship of the carriage of IL-10-1080 G/A and IL-28 rs8099917 C/T polymorphisms to the course of lupus nephritis (LN).

Subjects And Methods: Ninety-nine patients with systemic lupus erythematosus (SLE), including 68 with LN, were examined. Gene polymorphisms were analyzed using standard molecular genetic techniques. The frequency of the clinical manifestations of LN was analyzed; renal survival (RS) was estimated by the Kaplan-Meier method.

Results: Ten-year RS rates were 80 and 86% of the patients with and without the mutant IL-10 allele, respectively (p = 0.78). The 10-year RS was lower (75%) in carriers of the mutant IL-28 rsl2979860 allele than in patients without this mutant allele (83%; p = 0.049) and in those of the mutant IL28 rs8099917 allele than in patients without the above mutant allele (67 and 88%, respectively; p = 0.047). LN patients, carriers of the mutant IL-10-1028 G/A allele, were observed to have higher-grade proteinuria in the presence of nephritic syndrome (mean 6.1 g/l) than those without the mutant allele of this gene (mean 2.9 g/l; p = 0.034). However, the mutant allele carriers responded to treatment better (p = 0.050). The mutant IL-10 and IL-28 alleles were unassociated with the development of rapidly progressive nephritis, the activity of a renal lupus process, and the rate of onset of SLE and LN.

Conclusion: In the LN patients, the carriage of the mutant IL-10 allele A is associated with a better response to treatment and that of the mutant IL-28 allele is linked to the severe course of the disease.

Download full-text PDF

Source
http://dx.doi.org/10.17116/terarkh201587640-44DOI Listing
September 2015
50 Reads

Publication Analysis

Top Keywords

mutant allele
16
mutant il-10
12
patients mutant
12
mutant
11
allele
10
carriers mutant
8
mutant il-28
8
gene polymorphisms
8
allele patients
8
il-10 allele
8
course lupus
8
patients
6
nephritis activity
4
10-year lower
4
078 10-year
4
75% carriers
4
il-28 rsl2979860
4
rsl2979860 allele
4
rapidly progressive
4
allele 078
4

References

(Supplied by CrossRef)

Similar Publications