Nectins and nectin-like molecules: roles in cell adhesion, polarization, movement, and proliferation.

IUBMB Life 2006 May-Jun;58(5-6):334-43

Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine/Faculty of Medicine, Suita, Osaka, Japan.

Nectins and nectin-like molecules (Necls) are immunoglobulin-like cell adhesion molecules that constitute families containing four and five members, respectively. All members, except for Necl-5, trans-interact homophilically. Furthermore, all members, including Necl-5, trans-interact heterophilically with their respective specific partners among the members. Necl-5 regulates cell movement and proliferation cooperatively with integrin alphavbeta3 and growth factor receptors. Nectins function as cell-cell adhesion molecules at a variety of cell-cell junctions, including adherens junctions, and regulate the initial step of cell-cell junction formation. Nectins and integrin alphavbeta3 are further involved in the cross-talk between cell-matrix and cell-cell junctions. Thus, both nectin and Necl family members play important roles in fundamental cellular functions, including cell adhesion, polarization, movement, and proliferation.

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http://dx.doi.org/10.1080/15216540600719622DOI Listing
September 2006
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