Rearrangement of the p53 gene in human osteogenic sarcomas.

Proc Natl Acad Sci U S A 1987 Nov;84(21):7716-9

Department of Medicine, University of California, Los Angeles 90024.

p53 is a 53-kDa nuclear protein that is associated with malignant transformation in several tumor model systems. In a survey of 134 human carcinomas, sarcomas, leukemias, and lymphomas obtained at surgery or from peripheral blood, we found rearrangements of the p53 gene only in osteogenic sarcomas (3 of 6 osteogenic sarcomas examined). Normal tissue from one of these patients had an unrearranged gene, indicating that the genetic abnormality in the tumor was acquired. Two of the sarcomas with rearranged genes expressed levels of p53 protein that were elevated relative to other tumors. Rearranged p53 genes were also found in human osteogenic sarcoma cell lines.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC299371PMC
http://dx.doi.org/10.1073/pnas.84.21.7716DOI Listing
November 1987

Publication Analysis

Top Keywords

osteogenic sarcomas
12
human osteogenic
8
p53 gene
8
sarcomas
5
patients unrearranged
4
tissue patients
4
gene indicating
4
abnormality tumor
4
genetic abnormality
4
indicating genetic
4
normal tissue
4
unrearranged gene
4
sarcomas osteogenic
4
peripheral blood
4
surgery peripheral
4
lymphomas surgery
4
rearrangements p53
4
gene osteogenic
4
sarcomas examined
4
tumor acquired
4

Altmetric Statistics

Similar Publications