The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites.

Authors:
J Shine L Dalgarno

Proc Natl Acad Sci U S A 1974 Apr;71(4):1342-6

With a stepwise degradation and terminal labeling procedure the 3'-terminal sequence of E. coli 16S ribosomal RNA is shown to be Pyd-A-C-C-U-C-C-U-U-A(OH). It is suggested that this region of the RNA is able to interact with mRNA and that the 3'-terminal U-U-A(OH) is involved in the termination of protein synthesis through base-pairing with terminator codons. The sequence A-C-C-U-C-C could recognize a conserved sequence found in the ribosome binding sites of various coliphage mRNAs; it may thus be involved in the formation of the mRNA.30S subunit complex.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC388224PMC
http://dx.doi.org/10.1073/pnas.71.4.1342DOI Listing
April 1974

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