Droplet microfluidics.

Lab Chip 2008 Feb 11;8(2):198-220. Epub 2008 Jan 11.

Department of Biomedical Engineering, University of California, Irvine, CA 92697, USA.

Droplet-based microfluidic systems have been shown to be compatible with many chemical and biological reagents and capable of performing a variety of "digital fluidic" operations that can be rendered programmable and reconfigurable. This platform has dimensional scaling benefits that have enabled controlled and rapid mixing of fluids in the droplet reactors, resulting in decreased reaction times. This, coupled with the precise generation and repeatability of droplet operations, has made the droplet-based microfluidic system a potent high throughput platform for biomedical research and applications. In addition to being used as microreactors ranging from the nano- to femtoliter range; droplet-based systems have also been used to directly synthesize particles and encapsulate many biological entities for biomedicine and biotechnology applications. This review will focus on the various droplet operations, as well as the numerous applications of the system. Due to advantages unique to droplet-based systems, this technology has the potential to provide novel solutions to today's biomedical engineering challenges for advanced diagnostics and therapeutics.

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http://dx.doi.org/10.1039/b715524gDOI Listing
February 2008
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References

(Supplied by CrossRef)

Whitesides et al.
Nature 2006

Manz et al.
Sens. Actuators, B 1990

deMello et al.
Nature 2006

El-Ali et al.
Nature 2006

Weibel et al.
Curr. Opin. Chem. Biol. 2006

Dittrich et al.
Anal. Chem. 2006

Atencia et al.
Nature 2005

Stone et al.
Annu. Rev. Fluid Mech. 2004

Squires et al.
Rev. Mod. Phys. 2005

Lucchetta et al.
Lab Chip 2006

Jeon et al.
Nat. Biotechnol. 2002

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