Cross-regulation of histone modifications.

Nat Struct Mol Biol 2007 Nov 5;14(11):1017-24. Epub 2007 Nov 5.

Program in Genes and Development, Department of Biochemistry and Molecular Biology and Center for Epigenetics, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

Histones undergo several different post-translational modifications that control a variety of physiological processes. These covalent modifications show substantial cross-regulation, providing a wealth of regulatory potential. New insights into the communication between modifications on histones have emerged in recent years. This review assesses the current understanding of cross-regulation of histone modifications and identifies future questions to be addressed in this field.

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http://dx.doi.org/10.1038/nsmb1307DOI Listing
November 2007
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