Linking lipids to Alzheimer's disease: cholesterol and beyond.

Nat Rev Neurosci 2011 May 30;12(5):284-96. Epub 2011 Mar 30.

Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, 630 West 168th Street, New York, New York 10032, USA.

Lipid-mediated signalling regulates a plethora of physiological processes, including crucial aspects of brain function. In addition, dysregulation of lipid pathways has been implicated in a growing number of neurodegenerative disorders, such as Alzheimer's disease (AD). Although much attention has been given to the link between cholesterol and AD pathogenesis, growing evidence suggests that other lipids, such as phosphoinositides and phosphatidic acid, have an important role. Regulators of lipid metabolism (for example, statins) are a highly successful class of marketed drugs, and exploration of lipid dysregulation in AD and identification of novel therapeutic agents acting through relevant lipid pathways offers new and effective options for the treatment of this devastating disorder.

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May 2011
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References

(Supplied by CrossRef)

C Haass et al.
Nature Rev. Mol. Cell Biol. 2007

RE Tanzi et al.
Cell 2005

C Ballatore et al.
Nature Rev. Neurosci. 2007

SA Small et al.
Neuron 2008

P Foley et al.
Biochim. Biophys. Acta 2010

EH Corder et al.
Science 1993

L Bertram et al.
Nature Rev. Neurosci. 2008

G Bu et al.
Nature Rev. Neurosci. 2009

J Kim et al.
Neuron 2009

T Hartmann et al.
J. Neurochem. 2007

JM Dietschy et al.
Curr. Opin. Lipidol. 2001

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