Regulatory roles of natural antisense transcripts.

Nat Rev Mol Cell Biol 2009 Sep 29;10(9):637-43. Epub 2009 Jul 29.

Molecular and Integrative Neurosciences Department, The Scripps Research Institute, Jupiter, Florida 33458, USA.

Mammalian genomes encode numerous natural antisense transcripts, but the function of these transcripts is not well understood. Functional validation studies indicate that antisense transcripts are not a uniform group of regulatory RNAs but instead belong to multiple categories with some common features. Recent evidence indicates that antisense transcripts are frequently functional and use diverse transcriptional and post-transcriptional gene regulatory mechanisms to carry out a wide variety of biological roles.

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http://dx.doi.org/10.1038/nrm2738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850559PMC
September 2009
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