Understanding alternative splicing: towards a cellular code.

Nat Rev Mol Cell Biol 2005 May;6(5):386-98

Department of Biochemistry, 80 Tennis Court Road, University of Cambridge, CB2 1GA, UK.

In violation of the 'one gene, one polypeptide' rule, alternative splicing allows individual genes to produce multiple protein isoforms - thereby playing a central part in generating complex proteomes. Alternative splicing also has a largely hidden function in quantitative gene control, by targeting RNAs for nonsense-mediated decay. Traditional gene-by-gene investigations of alternative splicing mechanisms are now being complemented by global approaches. These promise to reveal details of the nature and operation of cellular codes that are constituted by combinations of regulatory elements in pre-mRNA substrates and by cellular complements of splicing regulators, which together determine regulated splicing pathways.

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrm1645DOI Listing
May 2005
23 Reads

Publication Analysis

Top Keywords

alternative splicing
16
splicing
6
investigations alternative
4
gene-by-gene investigations
4
traditional gene-by-gene
4
splicing mechanisms
4
complemented global
4
approaches promise
4
global approaches
4
decay traditional
4
mechanisms complemented
4
rnas nonsense-mediated
4
hidden function
4
splicing hidden
4
proteomes alternative
4
function quantitative
4
quantitative gene
4
promise reveal
4
control targeting
4
gene control
4

References

(Supplied by CrossRef)

C Burge et al.
1999

MS Jurica et al.
Mol. Cell 2003

L Cartegni et al.
Nature Rev. Genet. 2002

JF Caceres et al.
Trends Genet. 2002

NA Faustino et al.
Genes Dev. 2003

F Pagani et al.
Nature Rev. Genet. 2004

B Modrek et al.
Nature Genet. 2002

JM Johnson et al.
Science 2003

D Kampa et al.
Genome Res. 2004

TA Thanaraj et al.
Nucleic Acids Res. 2003

Q Pan et al.
Trends Genet. 2005

Similar Publications