A-to-I editing of coding and non-coding RNAs by ADARs.

Authors:
Kazuko Nishikura

Nat Rev Mol Cell Biol 2016 Feb 9;17(2):83-96. Epub 2015 Dec 9.

The Wistar Institute, Department of Gene Expression and Regulation, 3601 Spruce Street, Philadelphia, Pennsylvania 19104-4268, USA.

Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine in double-stranded RNA. This A-to-I editing occurs not only in protein-coding regions of mRNAs, but also frequently in non-coding regions that contain inverted Alu repeats. Editing of coding sequences can result in the expression of functionally altered proteins that are not encoded in the genome, whereas the significance of Alu editing remains largely unknown. Certain microRNA (miRNA) precursors are also edited, leading to reduced expression or altered function of mature miRNAs. Conversely, recent studies indicate that ADAR1 forms a complex with Dicer to promote miRNA processing, revealing a new function of ADAR1 in the regulation of RNA interference.

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrm.2015.4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824625PMC
February 2016
9 Reads

Publication Analysis

Top Keywords

a-to-i editing
8
editing coding
8
unknown microrna
4
remains unknown
4
editing remains
4
microrna mirna
4
alu editing
4
precursors edited
4
leading reduced
4
edited leading
4
significance alu
4
mirna precursors
4
encoded genome
4
sequences result
4
coding sequences
4
repeats editing
4
alu repeats
4
result expression
4
expression functionally
4
reduced expression
4

References

(Supplied by CrossRef)

BL Bass et al.
Cell 1987

BL Bass et al.
Cell 1988

RW Wagner et al.
Proc. Natl Acad. Sci. USA 1989

M Hogg et al.
Adv. Genet. 2011

K Nishikura et al.
Annu. Rev. Biochem. 2010

A Athanasiadis et al.
PLoS Biol. 2004

L Bazak et al.
Genome Res. 2014

M Blow et al.
Genome Res. 2004

D Fumagalli et al.
Cell Rep. 2015

L Han et al.
Cancer Cell 2015

DD Kim et al.
Genome Res. 2004

Similar Publications