Activation and regulation of the inflammasomes.

Nat Rev Immunol 2013 Jun;13(6):397-411

Institute of Innate Immunity, University Hospital, University of Bonn, Bonn 53127, Germany.

Inflammasomes are key signalling platforms that detect pathogenic microorganisms and sterile stressors, and that activate the highly pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18. In this Review, we discuss the complex regulatory mechanisms that facilitate a balanced but effective inflammasome-mediated immune response, and we highlight the similarities to another molecular signalling platform - the apoptosome - that monitors cellular health. Extracellular regulatory mechanisms are discussed, as well as the intracellular control of inflammasome assembly, for example, via ion fluxes, free radicals and autophagy.

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http://www.nature.com/articles/nri3452
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http://dx.doi.org/10.1038/nri3452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807999PMC
June 2013
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