Coordinated regulation of myeloid cells by tumours.

Nat Rev Immunol 2012 Mar 22;12(4):253-68. Epub 2012 Mar 22.

H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33647, USA. dmitry.gabrilovich@ moffitt.org

Myeloid cells are the most abundant nucleated haematopoietic cells in the human body and are a collection of distinct cell populations with many diverse functions. The three groups of terminally differentiated myeloid cells - macrophages, dendritic cells and granulocytes - are essential for the normal function of both the innate and adaptive immune systems. Mounting evidence indicates that the tumour microenvironment alters myeloid cells and can convert them into potent immunosuppressive cells. Here, we consider myeloid cells as an intricately connected, complex, single system and we focus on how tumours manipulate the myeloid system to evade the host immune response.

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http://www.nature.com/articles/nri3175
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http://dx.doi.org/10.1038/nri3175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587148PMC
March 2012
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