Studying the mononuclear phagocyte system in the molecular age.

Nat Rev Immunol 2011 Oct 25;11(11):788-98. Epub 2011 Oct 25.

Department of Oncological Sciences and Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA.

The mononuclear phagocyte system (MPS) comprises monocytes, macrophages and dendritic cells. Tissue phagocytes share several cell surface markers, phagocytic capability and myeloid classification; however, the factors that regulate the differentiation, homeostasis and function of macrophages and dendritic cells remain largely unknown. The purpose of this manuscript is to review the tools that are currently available and those that are under development to study the origin and function of mononuclear phagocytes.

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http://www.nature.com/articles/nri3087
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http://dx.doi.org/10.1038/nri3087DOI Listing
October 2011
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