How regulatory T cells work.

Nat Rev Immunol 2008 Jul;8(7):523-32

Department of Immunology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105-2794, USA.

Regulatory T (T(Reg)) cells are essential for maintaining peripheral tolerance, preventing autoimmune diseases and limiting chronic inflammatory diseases. However, they also limit beneficial responses by suppressing sterilizing immunity and limiting antitumour immunity. Given that T(Reg) cells can have both beneficial and deleterious effects, there is considerable interest in determining their mechanisms of action. In this Review, we describe the basic mechanisms used by T(Reg) cells to mediate suppression and discuss whether one or many of these mechanisms are likely to be crucial for T(Reg)-cell function. In addition, we propose the hypothesis that effector T cells may not be 'innocent' parties in this suppressive process and might in fact potentiate T(Reg)-cell function.

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http://dx.doi.org/10.1038/nri2343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665249PMC
July 2008
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References

(Supplied by CrossRef)

S Sakaguchi et al.
Immunol. Rev. 2001

EM Shevach et al.
Immunol. Rev. 2006

E Xystrakis et al.
Expert. Opin. Biol. Ther. 2006

JL Coombes et al.
Immunol. Rev. 2005

Y Belkaid et al.
Nature Rev. Immunol. 2007

BT Rouse et al.
Immunol. Rev. 2006

K Kretschmer et al.
Immunol. Rev. 2006

S Hori et al.
Science 2003

JD Fontenot et al.
Nature Immunol. 2003

CL Bennett et al.
Nature Genet. 2001

RS Wildin et al.
Nature Genet. 2001

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